摘要
目的:探讨幽门螺杆菌感染(Hp)儿童胃窦粘膜及胃液中降钙素基因相关肽(CGRP)的变化。方法:32例Hp+的十二指肠溃疡(DU)患儿入选本研究。在奥美拉唑、克拉霉素及甲硝唑三联治疗之前和之后4～6周从DU患儿胃窦钳取粘膜组织及胃腔中吸取胃液,应用放免法测定其中CGRP的含量。Hp感染采用快速尿素酶试验和组织学检查来判定。30例Hp-非消化系病患儿为对照。结果:患儿胃窦粘膜与胃液CGRP水平在Hp+组均显著低于Hp-组(P<0.01),粘膜CGRP水平与胃液CGRP水平经相关性分析呈正相关(r=0.58,P<0.05)。经三联疗法治疗后,Hp感染被根除,溃疡愈合,胃窦粘膜及胃液中CGRP水平较Hp+组明显升高(P<0.01),接近Hp-组水平(P>0.05)。结论:CGRP可能在儿童Hp相关DU的发生发展中具有一定作用。
Objective To study the change of ealcitonin gene-related peptide （CGRP） in children with helieobaeter pylori （Hp）.Methods 32 patients with Hp positive （Hp＋）and duodenal ulcer （DU） were assessed in this study. Their antral tissues and gastric juice were got by gastroscopy before and affer 4-6 weeks＇ triple therpy with Ornerprozole,Clarithromyein,and rnetrinidazole.CGRP eoneertration was measured by using radioirnmunologieal assay.Hp infection was identified by rapid urease test and histology. 30 patients without gastrointestinal disease and Hp infeetion（Hp-） were served as control.Results Prior to the treatment, CGRP in antral tissues and gastile juice in Hp＋ group were much lower than that of Hp- group; CGRP in antral tissues were positive correlated with that of gastric juice （r=0.58, P〈0.05）.After the treatment, CGRP in antral tissues and gastric juice in Hp^- eradicated group were significantly higher than that of Hp＋ group, and nearly returned to the levels of Hp- group （P〉0.05）.Conclusion CGRP may play critical roles in the pathogenesis of Hpassociated DU in children.
出处
《安徽卫生职业技术学院学报》
2006年第4期52-53,共2页
Journal of Anhui Health Vocational & Technical College
关键词
幽门螺杆菌
胃粘膜
胃液
降钙素基因相关肽
ehildren
helieobaetor pylori
gastrie mueosa
gastric juice
ealeitonin gene-related peptide
