摘要
目的探讨胸水IL-18在结核性和恶性胸腔积液的水平和意义。方法选取2004年1月￣2005年5月在哈尔滨医科大学附属第二医院呼吸内科住院的未经治疗的胸腔积液患者48例,其中结核性胸腔积液组24例,恶性胸腔积液组24例。用酶联免疫吸附法(ELISA)检测结核性和恶性胸腔积液中IL-18浓度。结果结核性胸腔积液组IL-18浓度(263.37±67.64)ng/L显著高于恶性胸腔积液组(92.15±26.66)ng/L(P<0.05)。以胸水IL-18150ng/L为临界值,对结核性胸腔积液组诊断敏感性83%、特异性91.7%、准确性87.5%。
[Objective] To evaluate the level of interlukin 18 and its significance in tuberculous pleural effusion and malignant pleural effusion. [Methods] We selected 48 patients of pleural effusion in the wards of Department of Respiratory Internal Medicine, the Second Affiliated Hospital of Harbin Medical University during January 2004 and May 2005. Forty-eight specimens of pleural effusions were collected from 48 patients with pleural effusion. Of them 24 pleural effusion were diagnosed as tuberculous, and 24 as malignant. The levels of IL-18 of pleural effusion in tubercular pleurisy and malignant pleural effusion sufferersly were detected by ELISA. [Results] The level of IL-18 in tuberculous effusion （263.37±67.64） ng/L was significant higher than that in malignant pleural effusion （92.15±26.66） ng/L （P 〈0.05）. The cut-of values for the IL-18 was defined. It was 150 ng/L. The sensitivity and specificity of IL-18 for tuberculous pleural effusion were 83.0% and 91.7%. [Conclusion] IL-18 could be used as valuable parameters for the differentiation of tuberculous effusion from malignant.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2006年第15期2356-2357,2360,共3页
China Journal of Modern Medicine
