摘要
目的:探讨肌钙蛋白T(cTnT)、IL-8和TNF-α在病毒性心肌炎(VMC)诊断及预后中的价值。方法:对86例VMC患者进行入院后1个月、6个月以内及6个月以上cTnT、IL-8和TNF-α的动态检测,并与正常对照组30例的检测结果进行比较。结果:VMC组急性期cTnT、IL-8和TNF-α阳性率(47.67%、65.12%和74.41%)较6个月以内组(34.32%、46.23%和41.79%)、6个月以上组(15.79%、21.05%和10.52%)及正常对照组(0%)显著升高(P<0.01);病程6个月以内组cTnT、IL-8和TNF-α阳性率较6个月以上组升高(P<0.05)。cTnT阳性者急性期的治愈率(12.2%,5/41)显著低于阴性者(48.8%,21/45)(P<0.005);cT-nT阳性者6个月以内组的治愈率(63.4%,26/41)显著低于阴性者(91.1%,41/45)(P<0.005)。结论:cTnT、IL-8和TNF-α是有助于及早诊断VMC即敏感又特异的指标,在VMC预后判断中具有重要意义。
Objective To investigate the value of determination of blood cardiac troponin T （cTnT）, IL -8 and TNF-α conttents for the diagnosis and prognosis assessment in patients with viral myocarditis （VMC）. Methods Plasma cTnT （with immuno-infiltration method） and serum IL- 8, TNF （with ELISA） contents were measured in 86 patients with VMC at different stages （1 months, 〈 6 months, 〉 6 months）, and 30 controls. Results The positive rates of blood cTnT, IL- 8 and TNF-α in acute VMC patients were significantly higher than those in patients with history less than 6 months as well as with history more than 6 months and the controls group （P 〈 0.01 ）. The positive rates of cTnT, IL - 8 and TNF-α in cases with of history less than 6 months were significantly higher than cases with of history more than 6 months （ P 〉 0.05 ）. The cure rate in patients with positive cTnT was significantly lower than that in patients with negative cTnT both at 1 months and 6 months （P 〈 0.005 ）. Conclusion Blood cTnT, IL -8 and TNF-α are sensitive and specific predictors for diagnosis and prognosis assessment in patients with VMC.
出处
《放射免疫学杂志》
CAS
2006年第4期303-304,共2页
Journal of Radioimmanology
关键词
心肌炎
心肌肌钙蛋白T
白介素-8
肿瘤坏死因子-α
myocarditis, cardiac troponin T, interleukin - 8 （ IL - 8 ）, tumor necrosis factor-α （TNF-α）
