摘要
目的探讨转化生长因子β1促进关节软骨缺损修复临床应用的可行性。方法关节镜下准确定位后电动刨削器清理边缘,后用"3mm钻头向股骨中轴方向钻孔至髓腔,术后第2天1ml(100ng)活化TGF-β1关节腔内注射,每周1次,连用3周。结果9例膝关节软骨缺损3￣9个月随访,优良率100%,未见骨软骨赘、创伤性骨关节炎和退行性改变发生。结论TGF-β1直接注射于关节腔内,能有效促进关节软骨缺损修复,临床应用前景广阔。
Objective To probe the feasibility in clinical use of the articular cartilage defect repair by transforming growth factorbetal. Methods Cleaned the edge with electric abrasive maching after orienttingaccurately under the arthroscope, Then drilled drill towards femur center-axix to pulp cavity by Ф3mm drill. The second day after operation, 1ml（100ng）activation TGF-β1 was injected to articular cavity, once a week and three weeks continued. Results 9 cases knee articular cartilage defect were followed-up 3-9 months, The good rate in 100% and no osteophyte, no traumatic arthritis and no retrograde affection, Conclusion It is effective to promote articular cartilage defect repair that TGF-β1 was injected to articular cavity directly. The clinical use outlook is widely.
出处
《中国现代医药杂志》
2006年第7期37-39,共3页
Modern Medicine Journal of China
关键词
转化生长因子
关节软骨
缺损
修复
Transforming growth factor betal Articular cartilage Defect Repair
