摘要
应用酶联亲和组化法及网格点计数方法，对３０例乳腺癌、３８例纤维腺瘤、３９例小叶增生及２３例非癌组织的雌激素受体（ＥＲ）和孕酮受体（ＰＲ）及细胞密度进行检测和分析。结果：①纤维腺瘤、小叶增生及非癌组织中ＥＲ、ＰＲ的阳性率均分别低于癌中的表达（Ｐ＜０．０５），纤维腺瘤与小叶增生之间受体表达无显著性差异（Ｐ＞０．０５）。②各组病变中细胞密度的高低与受体阳性表达有关（Ｐ＜０．０５）。提示：乳腺良性病变中ＥＲ、ＰＲ阳性率的不同，为临床内分泌治疗提供理论依据。
The determination and analysis of estrogen receptor(ER) and progesterone receptor(PR)and cellularity were performed On 30 cases of breast cancer,38 cases of fibroadenoma,39 cases of lobular hyperplasia and 23 non-malignant tissues with the enzyme-linked affinity histochemistry assay and point-counting method. The results showed that the positive rates of ER and PR in fibroadenomas,lobular hyperplasia and non-malignant tissues were significantly lower than those in breast cancer(P<0. 05). There was no significant difference between the receptor positive rates of the fibroadenoma and those of lobular hyperplasia. There was a positive correlation between the receptor value and cellularity in different breast benign and malignant lesions(P<0.05).This study suggests that the presence of ER and PR in breast lesions might provide theoretical basis for the clinical endocrine therapy.
出处
《河南医科大学学报》
1996年第4期37-40,共4页
Journal of Henan Medical University
关键词
乳腺癌
纤维腺瘤
雌激素受体
孕激素受体
breast carcinoma
fibroadenoma
benign breast disease
estrogen receptor
progesterone receptor
