摘要
目的评价bcl-2基因检测诊断肺癌血行转移的应用价值,观察抗癌中药卡宁对肺癌的疗效。方法应用半巢式-聚合酶链反应技术检测肺癌患者服用卡宁前后外周血bcl-2表达水平。结果非卡宁治疗组患者治疗前后bcl-2阳性率分别为55%和45%,卡宁治疗组bcl-2阳性率分别为60%和22.5%。治疗后卡宁组bcl-2基因表达阳性率显著低于非卡宁组(P<0.0),肺癌IV期患者bcl-2基因表达阳性率较肺癌期明显增高(P<0.01)。结论肺癌患者随肿瘤分期进展外周血bcl-2基因表达阳性率增高,抗癌中药卡宁治疗肺癌有较好疗效。
[Objective] To detect the value of bcl-2 gene on lung cancer blood metastasis diagnosis and evaluate the effect of Chinese herbs ＂caning＂ for lung cancer. [Methods] bcl-2 gene analysis was performed in patients with lung cancer by semi-nested-polymerase chain reaction before and after treatment. [Results] The positive rate of bcl-2 gene rate is in the control group of lung cancer patients was 55% before treatment and 45% after treatment and was 60% and 22.5% in the experimental group. The positive rate of the experimental group was lower than that of the control group （P〈0. 05）. The bcl-2 positive rat of stage IV was high significantly than that of stageⅢlung cancer （P〈0.01）. [Conclusions] The level of bcl-2 gene increases in peripheral blood of lung cancer with the stage increasing. Chinese herbs ＂caning＂ has effect on lung cancer.
出处
《山东医药》
CAS
北大核心
2006年第22期14-15,共2页
Shandong Medical Journal
基金
广州市卫生局中西医结合基金资助项目(052402)。
关键词
BCL-2
凋亡
肺肿瘤
肿瘤转移
中草药
bcl-2
apotosis
lung neoplasms
tumor metastasis
Chinese herb
