摘要
目的:探讨睡眠呼吸暂停综合征(SAS)与高血压之间的关系及其形成机制。方法:比较54例SAS患者和54例对照者一般睡眠打鼾者高血压的发病率和睡前、醒后收缩压、舒张压,并将睡前、醒后收缩压、舒张压与睡眠呼吸暂停低通气指数(AHI)、夜间最低SaO2(SaO2-min)进行相关分析。结果:SAS组合并高血压的发病率高于对照组。SAS组醒后的收缩压和舒张压均较睡前增高,对照组醒后的收缩压和舒张压较睡前均无明显变化。SAS患者睡前及醒后SBP、DBP与AHI均呈正相关,睡前DBP与SaO2-min呈负相关,且前四个相关系数绝对值均较后者大,而睡前SBP、醒后SBP及DBP与SaO2-min无显著相关。结论:SAS与高血压相关,且是高血压的一个独立危险因素。缺氧可能不是SAS合并高血压的主要机制。
Objective： To explore the correlation between sleep apnea syndrome （SAS） and hypertension, and the pathogeny of hypertension as a result of SAS. Methods： The incidence of hypertension, pre-sleep systolic blood pressure （SBP） and diastolic blood pressure （DBP） and post-sleep SBP and DBP were compared between 54 cases of SAS and 54 cases in the control group, and the correlations were analyzed between pre-sleep and post-sleep SBP, DBP and A HI and lowest arterial oxygen saturation （SaO2·min）. Results. The incidence of hypertension as a complication of SAS in the SAS group was higher than that in the control group. The post-sleep SBP and DBP were higher than pre -sleep SBP and DBP in the SAS group, while there were no significant differences in the control group. The pre- sleep and post-sleep SBP and DBP were positively correlated with AHI, and pre-sleep DBP was negatively correlated with SaO2·min. The absolute values of the correlation confficients of the former correlations were higher than that of the latter. There were no significant correlations between pre-sleep SBP, post-sleep SBP, post-sleep DBP and SaO2·min. Conclusion： SAS is correlated with hypertension and is an independent risk factor for hypertension. Hypoxia might not be the major pathogeny of hypertension in SAS patients.
出处
《医学理论与实践》
2006年第8期894-895,共2页
The Journal of Medical Theory and Practice
