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恶性淋巴瘤患儿血清一氧化氮、血浆内皮素变化及其临床意义 被引量:1

Changes of Nitric Oxide and Endothelin Levels in Children with Lymphoma and Its Clinical Significance
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摘要 目的探讨恶性淋巴瘤患儿血清一氧化氮(NO)、血浆内皮素(ET)变化及其临床意义。方法采用硝酸还原酶法、放射免疫法对39例恶性淋巴瘤患儿及33例健康体检儿(对照组)血清NO及ET水平进行测定。结果恶性淋巴瘤患儿治疗前NO及ET水平高于对照组(P均<0.001);Ⅲ、Ⅳ期高于Ⅰ、Ⅱ期患儿;缓解者接近对照组水平(P>0.05);复发患儿高于缓解患儿(P<0.001)。结论NO及ET可能与儿童恶性淋巴瘤发生、发展有关;动态监测恶性淋巴瘤患儿血清NO及ET水平对辅助诊断、观察疗效及预后判断均有指导意义。 Objective To investigate the changes and clinical signficance of nitric oxide(NO) and endothelin(ET) in children with lymphoma. Methods NO and ET of 39 cases with lymphoma and 33 normal controls were examined by using nitrose reductase method and RIA method. Results Competed to normal controls, NO and ET were higher in children with lymphoma; smilar to normal controls in complete remission(CR) and partial remission(PR) ;relapse cases were higher than remission. Conclusions NO and ET could have relation to lymphoma in children, testing the changes of NO and ET have signficanc to the assistant diagnosis,observeing effect and judging prognosis.
作者 张华 邓燕艺
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2006年第15期1008-1009,共2页 Journal of Applied Clinical Pediatrics
关键词 淋巴瘤 恶性 一氧化氮 内皮素 儿童 lymphoma nitric oxide endothelin child
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