摘要
目的：研究同种带瓣血管移植后，受者的免疫反应及抗体变化。方法：选自１９９４年１０月至１９９５年２月间使用同种带瓣血管为补片材料的１２例先天性心脏病（先心病）患儿。取其移植前后的血清分别作为对照组与实验组。用免疫组化法，测定各血清与相应的供体动脉壁间的反应，观察抗体变化及抗原分布。结果：对照组及实验组术后７日内抗体检测为阴性；实验组术后第１０日、１４日抗体为阳性；抗原分布遍及动脉壁全层，但以内皮层最密集。临床上１２例患儿无死亡，未见发热等可能的免疫排斥现象，随访３～６个月，超声下未见有钙化及明显反流。结论：液氮保存的同种带瓣血管有抗原性，移植后可激活受体的免疫系统，产生特异性抗体，术前应做组织相容抗原（ＨＬＡ）及ＡＢＯ血型配型，并且术后短期使用免疫抑制剂。
Objective:To study the immunoreaction after transplantation of cryopreserved homograft valved artery. Method:From October 1994 to February 1995,12 cases of congenital heart disease underwent transplantation of cryopreserved homograft valved artery.Immunohistochemistry was used to detect the immunoreactions of the patients sera before and after transplantation with the corresponding homograft valved arteries. Results:Antibody detections were negative before and within 7 days after operation,but positive at the 10 th and 14 th days involving the whole layer of the arterial wall,especially the endothelium layer. Conclusion:The cryopreserved homograft valved artery is antigenic.So HLA and ABO compatibility should be tested before the operation and certain immunosuppressor should be used.
出处
《中国循环杂志》
CSCD
1996年第10期603-606,共4页
Chinese Circulation Journal
关键词
同种瓣
免疫反应
血管移植
Homograft valve
Lmmunoreaction (Chinese Circulation Journal,1996,11:603.)
