摘要
目的:研制水溶性药物盐酸地尔硫芯卓缓释固体分散体,减少其不良药物反应。方法:应用固体分散技术制备盐酸地尔硫卓芯缓释固体分散体,采用差示热分析方法进行固体分散体物相分析并对其进行体外溶出试验。结果:差示热分析证实药物以非晶型均匀分散于载体中。固体分散体的体外溶出速率受溶出递质、药物和载体的比例及固体分散体粒度大小的影响。稳定性试验表明,固体分散体放置3个月后,体外溶出速率和药物分散状态无明显变化。结论:盐酸地尔硫芯卓缓释固体分散体稳定,Ⅲ号丙烯酸树脂可以用来制备盐酸地尔硫卓芯缓释固体分散体。
OBJECTIVE To prepare diltiazem hydrochloride （DIL） sustained release dispersoid to reduce its side reaction. METHODS Diltiazem hydrochloride dispersoid was prepared by the technique of solid dispersion. The DSC was used to investigate the nature of the studied forms and the dissolution was detected. RESULTS The DSC showed that diltiazem hydrochloride dispersoid could be dispersed amorphously in carrier. The release rate was related to the dissolution medium, drug/carrier ratio and the granules size. Stability test showed that the release rate and the drug dispersion state didn＇t change significantly after storage over 3 months. CONCLUSION Diltiazem hydrochloride sustained release dispersoid is stable and can decrease side reaction.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2006年第8期961-963,共3页
Chinese Journal of Hospital Pharmacy
