摘要
AIM： To investigate the changes that occur in E-cadherin expression during the process of metastasis in colorectal cancer.METHODS： E-cadherin expression was detected by immunohistochemistry and two indices of expression were calculated which reflected the level of expression and the locations （membrane and cytoplasm）. Univariate and multivariate survival analyses were used to assess the value of these two E-cadherin indices as predictors of both disease-free （DFS） and disease-specific （DSS） survival. RESULTS： E-cadherin membrane index （MI）, but not cytoplasmic index （CI）, was significantly higher in primary tumors than their metastases （P = 0.0001）. Furthermore, both primary tumor MI and CI were higher among the patients who developed subsequent metastasis （P = 0.022 and P = 0.007, respectively）. Interestingly, both indices were higher in liver metastase compared to other anatomic sites （MI, P = 0.034 and CI, P = 0.022）. The CI of the primary tumors was a significant predictor of DFS （P = 0.042, univariate analysis）, with a strong inverse correlation between CI and DFS （P = 0.006, multivariate analysis）. Finally, the MI of primary tumor proved to be a significant independent predictor of DSS, with higher indices being associated with a more favorable outcome （P = 0.016）. CONCLUSION： Examination of E-cadherin expression and distribution in colorectal tumors can be extremely valuable in predicting disease recurrence. The observation that aberrant cytoplasmic expression of E-cadherin can predict disease recurrence is obviously of great importance for both patients and clinicians, and significantly affects decisions concerning the therapy and management of the patients.
瞄准：调查在颜色在转移的进程期间发生在 E-cadherin 表示的变化表面的癌症。方法：E-cadherin 表示被免疫组织化学检测，表示的二个索引是计算的它反映了表示和地点(膜和细胞质) 的水平。Univariate 并且多，变量幸存分析被用来作为两个的预言者估计这二个 E-cadherin 索引的价值没有疾病(DFS ) 并且疾病特定(决策支持系统) 幸存。结果：E-cadherin 膜索引(MI ) ，然而并非细胞质的索引(CI ) ，比他们的转移在原发性瘤是显著地更高的(P = 0.0001 ) 。而且，原发性瘤 MI 和 CI 在开发了随后的转移的病人之中是更高的(P = 0.022 并且 P = 0.007，分别地) 。有趣地，两个索引在与另外的解剖地点相比的肝转移是更高的(MI， P = 0.034 并且 CI， P = 0.022 ) 。原发性瘤的 CI 是 DFS 的一个重要预言者(P = 0.042， univariate 分析) ，与在 CI 和 DFS 之间的强壮的反的关联(P = 0.006，多变量分析) 。最后，原发性瘤的 MI 证明了是决策支持系统的一个重要独立预言者，与与更有利的结果被联系的更高的索引(P = 0.016 ) 。结论：在颜色的 E-cadherin 表示和分发的检查表面的肿瘤能在预言是极其珍贵的疾病复发。E-cadherin 的异常细胞质的表示能预言疾病复发为病人和临床医生显然是很重要的，并且显著地有关病人的治疗和管理影响决定的观察。
基金
Supported by grants from the Special Government Funding (EVO) allocated to Turku University Central Hospital
