摘要
目的:建立一种测定多硫酸肝素钠中硫酸基含量的方法。方法:将多硫酸肝素钠通过H+型阳离子树脂,用氢氧化钠对其洗脱液进行滴定,通过电导率的变化确定滴定终点,并用氯代十六烷基吡啶对结果进行校正,测定其硫酸基含量。结果:硫酸基的平均加样回收率为100．18％,RSD为3．67％。结论:本法简便准确,重复性较好。
Objective：To establish a method for the determination of the contents of sulfate groups in polysulfated heparin sodium. Methods ：The contents of sulfate groups were determined by converting the Na^＋ of polysulfated heparin sodium into H^＋ with cation exchange resin and titrating with sodium hydroxide. The titration end-point was ascertained by variance of conductivity and the results were rectified by cetylpyridinium chloride. Results：The average recovery was 100. 18% ,RSD = 3.67%. Conclusion：This mthod was simple, reproducible and accurate.
出处
《药学实践杂志》
CAS
2006年第4期205-206,共2页
Journal of Pharmaceutical Practice
