摘要
目的 了解我院院内感染常见病原菌构成及药物敏感状况。方法 采用半自动微生物分析仪（ATB）对细菌鉴定及药物敏感情况进行分析。结果 2005年我院院内感染前六位病原菌依次为大肠杆菌35株（23.3％）、金黄色葡萄球菌21株（14．0％）、肺炎克雷伯菌21株（14．0％）、铜绿假单胞菌20株（13.3％）、粪肠球菌10株（6．7％）、阴沟肠杆菌8株（5.3％），以上细菌占总检出率的76．7％，其余各类细菌占23.3％。革兰氏阳性球菌敏感药物依次为万古霉素、替考拉宁、利福平、磺胺甲基异哮唑。革兰氏阴性杆菌敏感药物依次为泰能、头孢吡肟、头孢他啶、阿米卡星。产ESBLs菌株发生率12．7％，为大肠杆菌13株（68．8％）、肺炎克雷伯菌6株（31．2％），均对泰能敏感。结论 正常菌群和条件致病菌正成为感染谱中的主要病原菌，万古霉素对革兰氏阳性球菌敏感；泰能、头孢吡肟对革兰氏阴性杆菌仍有较高敏感性。
Objective To understand the pathogen composition and drug susceptibility of nosocomial infection in our hospital. Methods The bacteria were identified and the drug-susceptibility tests were performed with ATB microbial half-auto-analyzer. Results The top six species were Escherichia coli 35（23.3%）, Staphylococcus aureus 21（14.0%）, Klebsiella pneumoniae 21（14.0%）, Pseudomonas aeruginosa 20（13.3%）, Enterococcus fecalis 10（6.7%）, and Enterobacter cloacae 8（5.3%）. Gram-positive bacteria were susceptible to Vancomycin, Timoplanin, Rifampin and Sulfamethoxazole. Gram-negative bacteria were susceptible to Tienam, Cefepime, Ceftazidime and Amikacin. The average positive rate of ESBLs positive bacteria was 12.7%, among them, the ratio of Escherichia and Klebsiella pneumoniae were 68.8% （13） and 31.2% （6）. They were susceptible to Tienam. Conclusions The normal bacteria flora and conditional pathogens are becoming main pathogens of the infectious diseases. But Gram-positive bacteria were susceptible to Vancomycin. Gram-negative bacteria were higher susceptible to Tienam, Cefepime.
出处
《世界感染杂志》
2006年第4期334-336,共3页
World Journal of Infection
关键词
细菌
耐药性
抗生素
bacteria
drug-resistance
antimicrobial
