摘要
目的比较射频治疗和传统放化疗在改善局部晚期非小细胞肺癌患者生存质量方面的作用。比较射频治疗和传统放化疗在肿瘤局部控制、1、2、5年生存率方面与传统放化疗的区别。方法采用密封随机化分组的信封将病人分别纳入综合组和常规组。两组均先给予2疗程化疗,2疗程化疗后评价降期可切除转手术治疗,终止本研究方案治疗;其余病人,常规组原发灶放疗(普通放疗或X刀治疗剂量共60GY);综合组原发灶行经皮肺穿射频治疗,如肺门、纵膈淋巴结有转移者加肺门和纵膈放疗。结果综合组和常规组比较,生存质量评分有明显增高,经统计学处理有非常显著性差异(P<0.05),治疗后的3、6个月生存质量评分也明显高于常规组(P<0.05)。1、2、5年生存率两组比较无显著性差异。结论射频毁损治疗能有效控制癌性疼痛,能明显增加患者体重,提高患者的生存质量,优于单纯放化疗。射频毁损治疗不能提高局部晚期非小细胞肺癌患者的1、2、5年生存率;远处亚临床转移是局部晚期非小细胞肺癌死亡的主要原因。
Objective To compare radiofrequency ablation with tradition chemotherapy or radiotherapy in the role of improving the life quality of local advanced non-small cell lung cancer, its security and validity in treating. To compare radiofrequency ablation to tradition chemotherapy or radiotherapy in the role of improving the part recurring rate, the median survival period, 1-yr 2-yr and 5-yr survival rate of non-small cell lung cancer. Methods Adopting airtight to take the envelope that was divided into groups including separately patient in synthesizing group and routine group at random. 2 course of treatment chemotherapy first at two groups 2 course of treatment chemotherapy for some cases become respectable by post-evaluations excision and passing on operation; other patients, former focus of routine group by radiotherapy （ordinary radiotherapy 60 GY /the 30th times and X knife）; former focus of synthesizing group passing through the treatment by percutaneous lung puncture radiofrequency, if the lymph gland in mediastinum or lung door exist shifts add lung door and mediastinum radiotherapy. Results Compared with routine group, the pain relief, the scores of KPS, body weight （BW） and Life quality in synthesizing group were markedly higher, there is significant differences in statistics（P〈0.05）.the scores of quality of life in Synthesizing group after treating 3 and 6 months were significant higher than routine group （P〈0. 05）. The median survival period, 1-yr 2-yr and 5-yr survival rate are not remarkable differences in two groups relatively. Conclusion Radiofrequency ablation can relief the pain of cancer effectively, can increase the patient＇s weight obviously, improve the patient＇s quality of life , is superior to chemotherapy or radiotherapy simply. Radiofrequency can not improve the median survival period, 1-yr 2-yr and 5-yr survival rate of Locally advanced Non-small Cell Lung Cancer; Consider that shift in inferior clinic in the distant place may be a main death cause of locally advanc
出处
《国际医药卫生导报》
2006年第13期20-23,共4页
International Medicine and Health Guidance News
关键词
射频毁损
局部晚期非小细胞肺癌
生存质量
生存率
radiofrequency ablation Local advanced non-small cell lung cancer Quality of life Survival rate
