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注射用核糖核酸Ⅰ制备工艺的改进 被引量:2

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摘要 目的改进用动物脏器制取核糖核酸Ⅰ的制备工艺,提高产品的质量和收率。方法采取冻融与少量苯酚、三氯甲烷并用一次萃取法,替代传统工艺用大剂量苯酚多次萃取法。结果用新工艺制备的3批制剂,各项检定指标均达到国家同类制品的质量标准,单位产量较传统工艺提高了50%,原材料成本显著下降。结论建立了适合大规模生产核糖核酸Ⅰ的制备方法。
出处 《中国生物制品学杂志》 CAS CSCD 2006年第4期418-419,共2页 Chinese Journal of Biologicals
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