人类白细胞抗原G与妊娠
摘要
妊娠期,母体免疫系统通过多种途径对带有父源性人类白细胞抗原(HLA)的胎儿形成免疫耐受。其中特异性表达在胎盘绒毛外细胞滋养层上(直接连接子宫蜕膜层与母体血液、子宫组织)的人类白细胞抗原G(HLA-G)在诱导母胎免疫耐受及维持正常妊娠中发挥重要作用,HLA-G通过多种途径诱导母胎耐受。对HLA-G的结构特点、受体、功能及其表达特点进行如下综述。
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