摘要
目的采用24小时动态血压监测观察比索洛尔／氢氯噻嗪复方片(Lodoz)治疗90例中国轻、中度高血压患者的降压效果和安全性。方法选择90例收缩压<180 mm Hg(1 mm Hg= 0．133 kPa),舒张压95-109 mm Hg的轻、中度高血压患者,口服Lodoz(2．5 mg/6．25 mg)共4周或Lodoz(5 mg／6．25 mg)8周,用24小时动态血压监测评价治疗4周、8周后动态血压变化及安全性。结果(1)4周和8周末诊室收缩压/舒张压分别降低(14．89±10．99)／(10．37±7．35)mm Hg和(19．40±10．55)／(13．31±7．77)mm Hg,全天、日间、夜间的24小时动态平均血压均明显降低,差异有统计学意义(P均<0．05)。4周和8周末的总有效率分别为59．3％和69．8％。(2)Lodoz(2．5 mg／6．25 mg)对收缩压和舒张压的谷／峰比值(T／P比值)分别为91．5％和94．4％,降压平滑指数(SI)为9．07／6．48;Lodoz(5 mg／6．25 mg)对收缩压和舒张压的T／P比值为79．9％和80．5％,SI为4．17／4．47。(3)Lodoz可能有使“非勺型”血压转变为“勺型”血压的趋势。(4)不良反应主要有血尿酸升高、头晕、头痛、腹泻、口干、肢端发凉、蚁行感,均为轻度。结论Lodoz能够持续、平稳、有效地降低24小时血压,且安全性良好。
Objective To investigate the efficacy and safety of bisorpolol/hydrochlorothiazide （Lodoz） in patients with mild and moderate essential hypertension. Methods After 2 weeks of placebo run-in period, 90 hypertensive patients with sitting diastolic blood pressure （ DBP ） between 95 and 109 mm Hg（ 1 mm Hg =0. 133 kPa） and systolic blood pressure （SBP） below 180 mm Hg were treated by Lodoz （2.5mg/6. 25mg/day） for4 weeks. If DBP 〉90 mm Hg at4 weeks, Lodoz （5mg/6. 25 mg/day） was given for another 8 weeks. Clinic systolic and diastolic blood pressure measurements and ambulatory blood pressure monitoring （ABPM） were performed at the end of placebo run-in period and at 4 and 8 weeks. Results After 4 or 8 weeks treatment with Lodoz, clinic systolic and diastolic blood pressure, the 24-hour mean, daytime and nocturnal blood pressures reduced significantly compared to placebo run-in period [SBP and DBP reduced （14.89 ± 10.99）/（10.37 ±7.35） mm Hg （4 weeks） and （19.40 ± 10. 55 ） / （ 13. 31 ± 7.77） mm Hg （ 8 weeks ） ] respectively （ P 〈 0. 05 ）. The total efficacy rate is 59. 3 % for Lodoz 2. 5mg/6. 25 mg and 69. 8% for Lodoz 5 mg/6. 25 mg. The trough：peak ratio for SBP and DBP were 91.5% and 94.4% with Lodoz 2.5mg/6.25 rag, and 79.9% and 80.5% with Lodoz 5mag/6.25 rag. The smoothness index （SI） for SBP and DBP were 9. 07 and 6.48 with Lodoz 2. 5mg/6. 25mg, and 4. 17 and 4. 47 with Lodoz 5 mg/6.25 mg, respectively. Few side effects were observed during treatment including mild headache and dizziness and slightly increased serum urea acid. Conclusion Lodoz （2. 5 mg/6. 25 mg and 5 mg/6. 25 mg） can effectively reduce the 24 hours blood pressure in patients with mild to moderate essential hypertension.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
2006年第7期605-608,共4页
Chinese Journal of Cardiology
关键词
高血压
比索洛尔
氢氯噻嗪
治疗结果
Hypertension
Bisorpolol
Hydrochlorothiazide
Treatment outcome
