摘要
目的：探讨早产儿甲状腺功能检测的时机和临床意义。方法：前瞻性对2003年8月-2005年7月本院住院101例早产儿，按是否有疾病分成观察A组（A组，单纯早产儿,n=36）和观察B组（B组，有疾病，n=65例）；同期出生30例正常足月儿作为对照组（C组），应用电化学发光法检测3组新生儿生后1、7天静脉血促甲状腺激素（TSH）、总甲状腺素（TT4）、总三碘甲状腺原氨酸（TT3）。结果：3组新生儿TSH、TT4、TT3第7天均低于第1天；A、B组TSH、TT4、TT3，均相应低于对照组；B组第1天TSH、TT4、TT3与A组无显著差异，第7天TT4、TT3低于A组，TSH高于A组；3组新生儿TT4／TSH第1天差异不明显，第7天对照组〉A组〉B组。结论：早产儿下丘脑-垂体-甲状腺轴发育不成熟，生后甲状腺功能可降低，危重早产儿甲状腺功能下降更明显；对早产儿特别是危重早产儿出生1周后检测甲状腺功能是必要的。
Objective： To explore the time and the clinical significance of observation on thyroid function on premature delivered infants. Methods： Serum thyroid - stimulating hormone （ TSH）, total thyroxine （TT4） and total triodothyrorine （ TT3 ） were detected by electrochemistry luminescence （ECL） in premature delivered infants on the 1st and 7th days from Aug 2003 to Jul 2005. They were divided into two groups according to the disease： the study group A, 36 premature delivered infants who had no other disease except premature; the study group B, 65 premature delivered infants Who had disease. And 30 normal neonates composed control group. Results： The concentrations of serum TSH, TT4, TT3 on the 1st day were lower than those on the 7th day in all three groups. The concentrations of serum TSH, TT4, and TT3 in study group A and B were lower than those in control group, those in group B showed no significantly differece with group A on the 1st day. TT4, TT3 in the group B were lower than group A while TSH were higher than group A on the 7th day, TT4/TSH in three groups showed no significantly difference on the 1 st day, while on the 7th day those-in control group were higher than group A and B. Conclusion： The thyroid function on the premature delivered infants is lower. It is more seriou in critical premature delivered infants. It is nessasery to detected the thyroid function on the premature delivered infants specially critical ones.
出处
《中国妇幼保健》
CAS
北大核心
2006年第14期1968-1969,共2页
Maternal and Child Health Care of China
关键词
早产儿
甲状腺功能
下丘脑-垂体-甲状腺轴
Premature infant
Thyroid function
Hypothalamus-pituitary- thyroid gland
