摘要
目的探讨TRUST和TPPA联合检测对梅毒的监控和诊治价值，为临床诊治梅毒提供更有价值的实验依据。方法采用TRUST法测定梅毒血清非特异类脂质抗原，TPPA法测定梅毒血清特异性螺旋体抗体。结果2003-2005年受检的7284人次中，TPPA法确证的梅毒656例，检出率为9．00％。2003年、2004年和2005年的检出率分别为6．54％，9．86％和10．26％。656例确证的梅毒中，TRUST法521例阳性，敏感性79．42％。TRUST法检出553例阳性中，32例经TPPA法确证为阴性，特异性为94．21％。TPPA法检出梅毒的阳性率明显高于TRUST法（χ^2=63．52，P〈0．005）。差异极显著。结论TRUST和TPPA联合检测为临床诊治梅毒提供更有价值的实验依据。更有利于梅毒的监控和诊治。
Objective To explore the diagnostic value of TRUST and TPPA for human syphilis, provide experimental theory for the clinic. Methods To analyze the outcomes of 7 284 sera detected by TRUST for non specific antigen and TPPA for specific antibody. Results The positive numbers of TPPA reagent for detecting 7 284 sera from 2003 to 2005 were 656, the positive rates was 9. 00%; the positive rates were 6. 54% ,9. 86%, 10. 26% in 2003, 2004, 2005 respectively. The positive numbers of TRUST reagent for detecting 656 positive sera were 521, sensitivity rate was 79. 52% , the false positive numbers of TRUST reagent for detecting 553 positive sera were 32, specificity rate was 94. 21%. The positive rates for detecting syphilis of TPPA reagent was higher than that of TRUST reagent, there were significant differences in the outcomes between TPPA reagent and TRUST reagent （χ^2= 63.52,P 〈 0. 005）. Conclusion TPPA in combination with TRUST test for diagnosing human syphilis provided valuable experimental theory, benefited for detecting and diagnosing of human syphilis in the clinic.
出处
《现代医院》
2006年第4期53-54,共2页
Modern Hospitals
