摘要
目的:探讨雌激素受体(ER)、孕激素受体(PR)和p53在原发性胆囊癌发生、发展中的作用及相互关系,研究它们的表达与胆囊癌的组织学类型、分化程度、临床分期及预后的关系。方法:用免疫组织化学法检测54例原发性胆囊癌组织中ER、PR和p53的表达水平。结果:54例原发性胆囊癌组织中ER、PR和p53阳性表达率分别为38.9%、37%和48.1%。p53的阳性表达与胆囊癌分化程度、临床分期密切相关,ER与PR的表达呈正相关,PR阳性的患者的累积生存率明显高与阴性者,临床分期和神经浸润与胆囊癌患者的预后有关。结论:p53的表达与胆囊癌分化程度、临床分期有关,ER与PR的表达呈正相关,PR的表达与临床分期和神经浸润与胆囊癌患者的预后有关。
Objective： To investigate the role of expression of estrogen receptor （ER）, progesterone receptor （PR） and p53 in the development of primary carcinoma of gallbladder, as well as the relationship of their expression with histological type, differenfiafion, clinical stage and prognosis in primary carcinoma of gallbladder. Method： Immunohistochemieal assay was employed to detect expression of ER, PR and p53 in 54 cases of primary carcinoma of gallbladder. Results： The positive rate of ER, PR and p53 was 38.9%. 37% and 48.1% respectively in 54 cases of primary carcinoma of gallbladder. The expression of p53 was correlated to the differentiation and clinical stage of carcinoma of gallbladder. There was positive correlation between expression of ER and PR. The PR positive patients have longer survival time than the PR negative ones. Clinical stage and liver invasion are both correlation with prognosis of carcinoma of gallbladder patients. Conclusion： The expression of p53 was correlated to the differentiation and chnical stage of carcinoma of gallbladder. There was positive correlation between expression of ER and PR. The expression of PR, clinical stage and liver invasion are correlation with prognosis of carcinoma of gallbladder patients.
出处
《华西医学》
CAS
2006年第3期512-514,共3页
West China Medical Journal
