期刊文献+

生物信息学在未来感染病学教学中的地位和作用 被引量:6

The Role of Bioinformatics in the Future Medical Education of Infectious Diseases
下载PDF
导出
摘要 生物信息学是在生命科学的研究中,以计算机为工具对生物信息进行储存、检索和分析的科学。它是当今生命科学和自然科学的重大前沿领域之一,同时也是21世纪包括临床医学在内的自然科学的核心领域之一。生物信息学对于感染性疾病中病原体,生物传播媒介,宿主的整体基因信息分析,抗感染药物的设计,耐药机制的阐明,疫苗的研发、个体化的预防策略等均有着日益重要的作用。作为一门新兴的交叉学科,它同感染病学临床教学有机的结合对于适应未来医学教育现代化的要求,提高医学生的信息素质,培养临床科研思维均有着重要意义。 Bioinformatics is a new field of science which takes the help of information technology for storage, retrieval & analysis of data and to simulate biological processes. Bioinformatics is important in the infectious diseases research including identification of pathogen, whole genome analysis of the cartier, antimicrobial agents design, development of vaccine, and management of drug- resistance. It is also in urgent need to integrate bioinformatics and modem medical education to renew our knowledge and improve the medical students to fit with the demand of future challenge of medical sciences.
出处 《华西医学》 CAS 2006年第3期474-476,共3页 West China Medical Journal
关键词 生物信息学 医学教育 感染病学 bioinformatics medical education infectious diseases
  • 相关文献

参考文献9

  • 1赵国屏等编著..生物信息学[M].北京:科学出版社,2002:189.
  • 2Lesk AM.Introduction to Bioinformatics[M].2002.Oxford University Press,New York,USA. 被引量:1
  • 3Jonathan Pevsner.Bioinformatics and Functional Genomics.Wiley-Liss:2003. 被引量:1
  • 4Bairoch A,Apweiler R.The SWISS-PROTEIN protein sequence database and its supplement TrEMBL in 2000[M].Nucl Acids Res,28:45-48. 被引量:1
  • 5Benson DA,Karsh-Mizrachi I,Lipman DJ et al.GenBnak[J].Nucl Acids Res 2000,28:15-18. 被引量:1
  • 6Baker W,Van den Broek A,Camon E et al.The EMBL nucleotide sequence database[M].Nucl Acids Res,2000,28:19-23. 被引量:1
  • 7Altschul SF,Gish W,Miller W et al.Basic local alignment search tool[J].J Mol Biol,1990,215(3):403-410. 被引量:1
  • 8Wlodawer A,Vondrasek J.Inhibitors of HIV-1 protease:a major success of structure-assisted drug design[M].Annu ReV Biophys Biomol Struct,1998,27:249-284. 被引量:1
  • 9Spaltmann F,Blunck M,Ziegelbauer K.Computer-aided target selection-prioritizing targets for antifungal drug discovery[M].Drug Discov Today,1999,4:17-26. 被引量:1

同被引文献47

  • 1李红梅.生物信息学课程教学实践与心得[J].农业与技术,2007,27(1):165-167. 被引量:10
  • 2师志云,王娅娜,马锐,于晶晶,于辛酉,高岭,赵巍.细粒棘球蚴中国大陆株诊断抗原P-29基因的克隆和序列分析[J].宁夏医学院学报,2007,29(4):337-339. 被引量:6
  • 3Verbon A, Hartskeerl RA, Sehttitema A, et al. The 14,000 moleceular - weight antigen of Mycobacterium tuberculosis is related to the alpha - crystallin family of low - molecular - weight heat shock proteins[ J ]. J Bacteriol, 1992,174 : 1352 - 1359. 被引量:1
  • 4Jacket PS,Bothamley GH, Barta HV, et al. Specificity of antibodes to immunodominant mycobsterial antigens in pulmnonary tuberoulosis[ J ]. J Clin Mierobiol, 1988,26: 2313 -2318. 被引量:1
  • 5Andersen AB, Hansen EB. Structure and mapping of antigentic domains of protein antigen b, 38000 - molecular - weight of Myeobacterium tuberculosis [ J ]. Infect Immun, 1989,57:2481 - 2488. 被引量:1
  • 6Arend SM, Engelhord AC, Groot G, et al. Tuberculin skin testing compared with T - cell responses to Myeobectedum tubercufosis specific and noaspecific antigens for detection of latent infection in persons with recent tuberculosis contact[ J]. Clin Diagn Lab Immunol ,2001, 8 : 1089 - 1096. 被引量:1
  • 7Doherty TM, Demissie A, Olobo J, et al. Immune responses to the Mycobacterium tuberculosis specific anti- gen ESAT -6 signal subclinical infection arroag contacts of tuberculosis patients [ J ]. J Clin Micmblol, 2002, 40 : 704 - 706. 被引量:1
  • 8Clarke R, Ressom HW, Wang A, et al. The properties of high -dimensional data spaces: implications for exploring gene and protein expression data [ J ]. Nat Rev Cancer,2008,8 ( 1 ) :37 - 49. 被引量:1
  • 9Elmasri R,Ji F, Fu J,et al. Modeling concepts and database implementation techniques for complex biological data [J]. Int J Bioinform Res Appl ,2007,3(3) :366 -388. 被引量:1
  • 10Suzuki H, Watkins DN, Jair KW, et al. Epigenetic inactivation ofSFRP genes allows constitutive Wnt signaling in colorectal cancer[J].Nat Genet,2004,36(4) :417 -422. 被引量:1

引证文献6

二级引证文献34

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部