摘要
目的:探讨HLA-DR、DQ基因单倍型与中国东北地区汉族人寻常型天疱疮的相关性。方法:应用序列特异性引物-聚合酶链反应(PCR-SSP)技术对27例中国东北汉族PV患者的HLA-DRB1、DQB1等位基因测定,进行单倍型分析,并与99例健康对照者进行比较。结果:与对照组比较,寻常型天疱疮患者组中单倍型DRB1140x-DQB10503、DRB1140x-DQB10201、DRB1120x-DQB10503和DRB1140x-DQB10302的频率明显增高,经统计学检验差异有显著意义(P<0·05)。结论:特异单倍型可能是决定寻常型天疱疮发生的重要因素。
Objective：To investigate the relationship between pemphigus valgaris （PV） and HLA-DR, DQ haplotypes in Han nations of northeast China. Methods：Polymerase chain reaction-sequence specific primers （PCR-SSP） method was used to detect the HLA-DRB1 and DQB1 alleles of 27 PV patients of Han nation of northeast China, analysed haplotyes and compared with 99 healthy controls. Results：Compared with control group, the frequencies of the haplotypes of HLA-DRB1 ＊ 140x-DQB1 ＊ 0503, DRB1 ＊ 140x- DQB1 ＊ 0201 ,DRB1 ＊ 120x-DQB1 ＊ 0503 and DRB1 ＊ 140x-DQB1 ＊ 0302 increased significantly in PV group. After statistical test, the difference between the two groups was significant. Conclusion：The special haplotypes may contribute to genetic susceptibility to PV in northeast Chinese.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2006年第5期453-455,共3页
Chinese Journal of Immunology
基金
辽宁省教育厅高等学校科学技术研究项目(2004D190)
