摘要
本文总结口服胺碘酮转复持续性房颤７０例的疗效，分析影响疗效的因素和毒副反应。结果：总有效率为７４．３％（５２／７０）。患者年龄、基础心脏病、左房内径大小对复律成功与否无影响。有影响的因素为房颤持续时间和心功能状态。用药后房颤的ｆ波幅升高，频率减慢，提示心功能改善，可预告复律将成功。胺碘酮的毒副反应轻，发生率低。但长期应用要警惕潜在的肺。
ThispaperreportstheeficacyandadversereactionoforalAmiodaroneinthetreatmentof70patientswithpersistentatrialfibrilation(Af).Theresultsshowedthatthetotalsuccesratewas74.3%(52/70).Theleftatrialsize,ageandunderlyingheartdiseasewerenothelpfulinpredictingtheresultatAmiodaronetherapy.ThedurationofAfandcardiacfunctionalconditionappearedtobeanadversefactor.Duringthetherapy,anincreaseintheamplitudeandadecreaseinthefrequencyofthefwaveintheAfpredictedconvertiontonor-malsinusrhythm,itshowsthattheheartfunctionswilbecomewel.Adversereactionsinmostcasesweremildandtolerable.However,inthelong-termapplicationtheoccurenceofpotentialserioussideefectsneedsatentionparticularlyinthelung,liverandneuralsys-tem.
关键词
心房纤颤
胺碘酮
心室功能
疗效
Amiodarone
atrialfibrilation
ventricularfunction
