摘要
^(125)I-IL－2脂质体及游离^(125)I-IL－2通过小鼠尾静脉给药后，观察其在主要脏器中的药物分布及血药浓度-时间曲线。结果表明，脾脏和肝脏对IL－2脂质体有较高的摄取，IL－2脂质体具有缓释作用；IL－2脂质体的血浆清除率明显低于单纯IL－2，其生物利用度明显提高。
After mice were intravenously injected with 125I-IL-2 liposome and free 125I-IL-2, the drug distribution in their main organs and drug concentration -time curve were observed. The authors found that most of the IL-2 liposome were distributed in spleens and livers and released slowly. The clearance rate of IL-2 liposome in plasma was significantly lower than that of free IL-2, and the bioavailability of IL-2 liposome was significantly im-proved.
出处
《中国生物制品学杂志》
CAS
CSCD
1996年第3期102-105,共4页
Chinese Journal of Biologicals
