摘要
目的研究结肠癌早期肝转移中缺氧诱导因子(HIF)和血管内皮生长因子(VEGF)表达及血管生成的相关性。方法2000年1月至2002年12月我院手术治疗的33例结肠癌息者,按术前及术后半年内有无肝转移分为早期肝转移组(15例)和早期无肝转移组(18例)。收集结肠癌组织标本,免疫组织化学方法检测肿瘤组织HIF、VEGF的表达和测定肿瘤微血管密度(MVD)。结果早期肝转移组HIF和VEGF的阳性表达率及MVD分别是86．7%、67．7%和(57．9±12．7)%；早期无肝转移组中的表达率为44．4%、27．8%和(22．3±10．2)%,早期肝转移组均显著高于早期无肝转移组(P＜0．05,P＜0．01)。结论结肠癌组织中的HIF能促进肿瘤血管形成,与早期肝转移有关。
Objective To study the relationships of hypoxia-induced factor （HIF） with tumor angiogenesis and early liver metastasis in colonic cancer. Methods Thirty three cases of colon cancer undergoing radical surgery were divided into two groups according to liver metastasis or not within half a year after operation. Expressions of HIF and vascular endothelial growth factor （VEGF） were examined using immunohistechemical method and tumor microvessel density （MVD） was measured in colonic cancer specimens. Results Fifteen cases developed early liver metastasis, while 18 did not. The positive rates of HIF and VEGF, and MVD were 86. 7% ,66. 7%, （57.9±12. 7）% respectively in the group with early liver metastasis, significantly higher than 44. 4% （ P 〈 0. 05）, 27. 8% （ P 〈 0. 05） and （22.3±10. 2）% （ P 〈 0. 01 ） respectively in the group without early liver metastasis respectively. Conclusion HIF can promote tumor angiogenesis in colonic cancer, and is closely related with early liver metastasis.
出处
《中华胃肠外科杂志》
CAS
2006年第4期349-351,共3页
Chinese Journal of Gastrointestinal Surgery
关键词
结肠肿瘤
缺氧诱导因子
血管内皮生长因子
肿瘤转移
Colonic neoplasms
Hypoxia-induced factor
Vascular endothelial growth factor
Neoplasms metastasis
