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血清可溶性细胞粘附分子与急性冠状动脉综合征患者近期心脏事件相关性研究 被引量:1

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摘要 目的探讨血清可溶性细胞粘附分子(CAMs)在急性冠状动脉综合征(ACS)发生发展过程中的作用。方法用双抗体ELISA法测定40例ACS患者及40例健康体检者血清可溶性细胞间粘附分子-1(sICAM-1)、血管细胞粘附分子-1(sVCAM-1)、E-选择素(sE-S)的浓度。结果ACS组血清sICAM-1、sVCAM-1及sE-S的浓度分别为(371.78±66.78)ng/ml、(644.91±169.73)ng/ml及(46.14±10.14)ng/ml,明显高于对照组的(236.45±47.55)ng/ml、(342.16±84.16)ng/ml及(31.30±5.40)ng/ml(均为P<0.01)。结论ICAM-1、VCAM-1、E-S参与了ACS的发病过程,且血清sICAM-1的水平与ACS患者近期急性心脏事件的发生呈正相关、与ACS患者的心功能呈负相关。
出处 《齐齐哈尔医学院学报》 2006年第7期785-787,共3页 Journal of Qiqihar Medical University
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