摘要
经动物实验及临床试用证实，克矽平、磷酸羟基哌喹、柠檬酸铝和汉防己甲素具有保护巨噬细胞、抑制矽性胶原化的作用。为探讨提高疗效、降低毒副反应，现提出不同或相同作用机制的药物联合用药治疗矽肺的设想。选用克矽平（气管注入）与汉防己甲素（口服）、柠檬酸铝（肌注）与磷酸羟基哌喹（口服）和汉防己甲素与磷酸羟基哌喹配合用药。联合用药组一种药物的剂量为各单独用药组的１／２，观察预防性治疗（３０～９０天）、病后治疗（９０～１８０天）及停药（９０天）后再治疗（９０天）对大鼠实验性矽肺的疗效。实验结果表明：在选用剂量条件下，各联合用药组，无论是预防性治疗还是病后治疗均表现出药效的相加作用——其疗效相当于或优于各相应单独用药组。停药后各组病变有不同程度的进展，联合用药组进展较缓；再给药后联合用药各组对病变恶化的控制作用优于相应的单独用药组。
It was proved that polyvinylpyridine-N-oxide (PVNO),aluminium citrate (ALC),quinolyl piperazine hydroxyphosphate (QOHP),and tetrandrine(TD)can inhibit silicotic fibrosis.In order to improve the therapeutic effects of these medicines rats with experimental silicosis were treated by combined use of medicines with similar or different mechanism. This study is composed of three parts:effect of preventive treatment on development of silicosis ,effect on silicosis,and influence of medicine withdrawal and repeated treatment after medicine withdrawal on silicosis .The combinations of medicines were PVNO+TD,ALC+QOHP and QOHP+TD.Lung wet weight,collagen content,total lipid,pathological classification of silicotic lesions were selected as parameters for comprehensive evaluation of therapeutic effects. The results of this study showed that therapeutic effects in three groups of combined use of medicines were more efficient than that of single use of relevant medicines even if half dose was used.
基金
本研究为国家"八五"攻关课题资助项目
关键词
矽肺
联合用药
药物疗法
Silicosis,Treatment ,Combined use of medicine ,PVNO,Aluminium citrate ,Quinolyl piperazinephosphate,Tetrandrine .
