摘要
目的了解2005年7月下旬至8月上旬发生在四川省的48例确诊为人猪链球菌病患者的临床特征。方法收集48例确诊为人猪链球菌病住院患者的资料,包括流行病学、临床表现、病原学、毒力基因鉴定结果、药敏试验等进行分析。结果1．从病死猪心血培养物、肝组织培养物分离到的细菌和从死亡患者脾组织培养物、患者血液、脑脊液培养物分离到的细菌经鉴定,均为猪链球菌2型；猪链球菌2型特异性毒力基因鉴定：猪链球菌2型毒力特异性基因(cps2J)、溶菌酶释放相关蛋白基因(mrp)、溶血素基因(sly)均阳性；药敏实验：对多种抗菌药物敏感；四环素、链霉素耐药；来自人的2株菌对环丙沙星中度敏感。2．48例确诊病例均有宰杀、肢解病死猪和直接接触猪血浆成分(血液、组织液)史。皮肤可见伤口者,感染率高。3．临床分为普通型、脑膜炎型、休克型、混合型四型,前两型预后良好。与本病相关的直接病死率为14．58%(7/48)。结论1．猪链球菌2型是本次人猪链球菌病的病原体,传染源是病猪。2．主要传播途径是直接接触病死猪的血浆成分；人经呼吸道传播无依据,无第2代患者产生。
Objective To investigate clinical characteristics of 48 cases verified to be infected with S. suis type 2. Methods 1. All data of 48 cases suffered from S. suis type2 infection were collected and analyzed. 2. Pathogenic gene of S. suis type 2, Such as cps 2A, mrp, and sly et al. , were verified by PCR. Results 1. Pathogenic gene of S. suis type 2 were same from those patients and swine. Drug sensitivity test were carried on and showed resistance to tetracycline and streptomycin. 2. All 48 cases had history to butchering and/or direct contacting blood plasma composition of suffering from or dead pigs. People with wound in the skin had higher risk to be infected. 3. Four clinical types were classified as general, meningitis. Shock and both shock combined meningitis. Mortality rate was 14.58%. Conclusion 1. S. suis type 2 was the pathogen leading to the infections of 48 cases in this study. The swine of suffering from the disease or dead were the origins of the transmission. 2. Main route of infection was butchering or/and direct contacting the plasma composition of being ill or dead pigs. No second generation of patients were found. 3. The cases with shock should be treated as early as possible. 4. Taking antibiotic were rational used seriously in human being and animals.
出处
《中华传染病杂志》
CAS
CSCD
北大核心
2006年第3期179-182,共4页
Chinese Journal of Infectious Diseases
关键词
链球菌感染
链球菌
猪
临床特征
四川
Streptococcal infections
Streptococcus suis
Clinical Characteristic
SiChuan
