摘要
采用化学药物引起急性肝损伤，观察黄芪总甙（ＴＧＡ）对小鼠肝脏的保护作用。实验结果表明，ＴＧＡ（４０、８０ｍｇ·ｋｇ－１·ｄ－１，ｉｇ×１０ｄ）可对抗四氯化碳（ＣＣｌ４，０．１％花生油溶液，１０ｍｌ·ｋｇ－１，ｉｐ）和醋氨酚（ＡＡｐ，２５０ｍｇ·ｋｇ－１，ｉｇ）引起的小鼠血清谷丙转氨酶、谷草转氨酶的升高，并对ＣＣｌ４和ＡＡＰ所致小鼠肝脏病理损伤有一定的保护作用。
The protective effects of total glucosides of astragalus membranaceous Bge(TGA)on liver injury induced by carbon tetrachloride(CCl4) and acetaminophen(AAP)in mice were investigated.The results showed that TGA(40,80 mg·kg-1·d-1,ig×10 d) could significantly inhibit the elevation of ALT and AST in serum induced by CCl4 and AAP.It was also found that TGA could reduce the liver lesion by CCl4 and AAP.
出处
《安徽医科大学学报》
CAS
1996年第4期267-269,共3页
Acta Universitatis Medicinalis Anhui
关键词
黄芪
药理学
四氯化碳
醋氨酚
肝损伤
astragalus membranaceus/pharm
liver/drug eff
liver/pathol
carbon.tetrachloride
acetaminophen
mice
