摘要
本项实验在８名志愿受试者身上采用交叉设计法，以日本产丙酸交沙霉素干糖浆为标准参比制剂，以微生物方法对国产丙酸交沙霉素干糖浆进行了生物利用度试验，结果表明两者的Ｃｍａｘ，Ｔｍａｘ，ＡＵＣ均无显著性差异，国内产品的相对生物利用度为１１７±２９％，说明两者为生物等效制剂。
sing microbiological method , the pharmacokinetic parameters and bioavailability of domestic josamycin propi-onate dry syrup were determined. With japanese Josamycin propionate dry syrup as standard reference formulation ,the experiment was conducted on eight healthy volunteers. The results showed that there were no significant dif-ference between two products in Cmax,Tmax and AUC. The relative bioavailability of demestic product was 117±29% ,And the two products were bioequivalent.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1996年第6期244-246,共3页
Chinese Journal of Hospital Pharmacy
关键词
丙酸交沙霉素
生物利用度
药物动力学
e josamycin propionate ,bioavailability ,pharmacokinetics
