摘要
目的探讨高危型人乳头瘤病毒杂交捕获法Ⅱ(HC2)评估宫颈上皮内瘤变的临床价值。方法回顾性分析了2002年3月至今在我院妇科门诊进行宫颈液基薄层细胞学(TCT)检测和HC2二联筛查的723例患者,以及其中进行TCT、HC2和阴道镜下多点活检三联检查的350例患者的临床资料。结果在TCT和HC2二联筛查的723例患者中,不典型鳞状细胞(ASC)组、低度鳞状上皮内病变(LSIL)组和高度鳞状上皮内病变(HSIL)组高危型HPV感染率分别为70·7%(94/133)、88·9%(249/280)和90·9%(90/99),均明显高于TCT正常组的55·5%(117/211)(P=0·005,P<0·001,P<0·001)。在TCT、HC2和阴道镜加点活检三联检查的350例患者中,宫颈轻度不典型增生(CIN1)组和宫颈中度不典型增生(CIN2)组高危型HPV感染率分别为88·9%(72/81)和96·3%(52/54),均明显高于病理学结果正常组的77·7%(153/197)(P=0·03,P=0·002);宫颈重度不典型增生(CIN3)组和子宫颈癌组高危型HPV感染率分别为91·7%(11/12)和100·0%(6/6),也呈明显升高趋势。在三联检查TCT为ASC的患者群中,高危型HPV感染率为79·3%(69/87)。其中高危型HPV感染者发生CIN2-3的比率为38·0%,明显高于无高危型HPV感染者的5·9%(P=0·04)。结论高危型HPV感染与宫颈癌前病变及子宫颈癌密切相关,其感染率随宫颈病变严重程度呈上升趋势。
Objective To evaluate the value of high-risk HPV （hrHPV） detection by Hybrid Capture Ⅱ （HC2） in screening cervical intraepithelial neoplasm （CIN）. Methods Totally 723 patients who had received a dual screening with thinprep cytologic test （TCT） and HC2 in our department were analyzed retrospectively. Among them, 350 patients received a triple examination with TCT, HC2, and colposcopic biopsy. Results Among the 723 patients, the incidences of hrHPV infection with atypical squamous cell （ ASC）, low squamous intraepithelial lesion, and high squamous intraepithelial lesion were 70.7% （ 94/133 ）, 88.9% （249/280） , and 90.9% （90/99） , respectively, significantly higher than 55.5% （ 117/211 ） , the incidence of hrHPV infection with normal cytological results （P = 0. 005, P 〈 0. 001, P 〈 0. 001, respectively）. Among 350 eases who were received triple examination, the incidence of hrHPV infection with cervical intraepithelial neoplasia （CIN） 1 and CIN 2 were 88.9% （72/81） and 96.3% （52/54） , significantly higher than 77.7% （ 153/197 ）, the incidence of hrHPV infection with normal pathological results （ P = 0. 03, P = 0. 002）; The incidence of hrHPV infection with CIN 3 and squamous cancer were 91.7% （11/12） and 100. 0% （6/6） , also higher than normal cases. Among these 350 cases, the incidence of hrHPV infection with ASC was 79. 3% （69/87）. The incidence of CIN 2-3 with ASC and hrHPV infection was 38.0% , significantly higher than the incidence of CIN 2-3 with ASC and without hrHPV infection （5.9%） （P = 0. 04）. Conclusion hrHPV infection has a close relation with CIN, and the incidence of hrHPV infection increases along with the severity of CIN.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2006年第3期395-398,共4页
Acta Academiae Medicinae Sinicae
