摘要
目的探讨盐酸纳洛酮对新生儿重度缺氧缺血性脑病患儿的疗效。方法将符合诊断的47例新生儿随机分为治疗组(25份)和对照组(22份),治疗组予以盐酸纳洛酮静滴,其余疗法两组相同,治疗前后两组均检测血中β-内啡肽水平、血气分析;2周时均行新生儿神经行为评分,并进行统计学分析。结果①β-内啡肽水平治疗组(5.38±2.61)较对照组(47.98±13.77)显著降低,P<0.01;②血气分析水平治疗组(76.05±10.38)较对照组(62.80±9.14)显著提高,P<0.01;③新生儿神经行为评分比较,治疗组较对照组效果显著(χ2=6.019,P<0.05)。结论盐酸纳洛酮从降低β-内啡肽水平、改善脑组织血氧供应等多个角度治疗重度缺氧缺血性脑病疗效明显。
Objective To determine the therapeutic effect of naloxone hydrochloride on the neonates with hypoxic-ischemic encephalopathy. Methods 47 neonates with hypoxic-ischemic encephalopathy were given naloxone hydrochloride. Data of blood gas analysis,β-EP and NBNA were analyzed. Results After 3-day-treatment of naloxone hydrochloride, blood gas analysis,β-EP were improved,both P〈0. 01. And after 14 days, NBNA were better than that in those without receiving naloxone hydrochloride therapy, P 〈 0. 05. Conclusion It is believed that naloxone hydrochloride is beneficial to patients with hypoxic-ischemic encephalopathy.
出处
《中国妇幼健康研究》
2006年第3期163-164,共2页
Chinese Journal of Woman and Child Health Research
