摘要
目的评价胃癌术后口服沙培林对胃癌远期疗效的影响。方法152例符合条件的胃癌手术后患者随机分为两组,单纯化疗组(对照组)75例,化疗加沙培林组(观察组)77例。对照组采用标准DF方案,观察组用DF方案加口服沙培林,进行前瞻性对比观察和为期5年的远期疗效评价。结果两组的毒性反应差异无显著性。远期疗效1,2,3,5的生存率观察组分别为84.4%(65/77)、75.3%(56/77)、67.5%(52/77)和61.0%(47/77);对照组分别为82.7%(62/75)、61.3%(46/75)、50.7%(38/75)和46.7%(35/65)。两组比较2,3,5年生存率差异均有显著性(P<0.05)。结论胃癌术后口服沙培林具有较好的耐受性和安全性,毒副作用无增加,主要仍表现为化疗药物的毒副作用,其远期疗效优于单纯化疗组。
Objective To evaluate the effect of oral administration of sapylin （OK-432） on longterm therapeutic effectiveness of postoperative stomach cancer. Methods A randomized clinical trial was undertaken to compare routine chemotherapy （DF regimen ） and routine chemotherapy plus sapylin. 152 eases with stomach cancer were observed and divided into 2 groups：77 cases in experimental group,using sapylin and DF regimen ,75 cases in control group using DF alone. Results Minor side effect and toxicity showed no significant difference between the 2 groups. The one-year survival rate, 2-year survival rate, 3-year survival rate and 5-year survival rate were 84.4% （65./77） ,75.3% （56/77） ,67.5% （52/77） ,61.0% （47/77） in experimental group, respectively,and 82.7% （62/75） ,61.3% （46/75） ,50.7% （38/75） ,46.7% （35/65） respectively in control group. Conclusions Oral administration of sapylin （ OK-432 ） plus routine chemotherapy regimen is more effective than routine chemotherapy regimen alone in treatment of postoperative stomach cancer. Sapylin is safe and effective.
出处
《中国肿瘤临床与康复》
2006年第3期284-286,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
胃肿瘤/化学疗法
沙培林
Stomach neoplasms/chemotherapy
Sapylin （OK-432）
