摘要
目的观察倍恩对恶性肿瘤患者化疗的疗效、毒性及生活质量的影响。方法将我科近几年收治的68例晚期恶性肿瘤患者随机分为倍恩联合化疗组(治疗组)及单纯化学治疗组(对照组)。治疗组采用倍恩500 mg,口服,每日2次,连服2周,每周期化疗前3 d开始用药,同时口服肠融阿斯匹林40 mg,每日1次,预防深静脉血栓形成;对照组单纯化学治疗。所有病例均接受2周期化疗。治疗前后进行疗效及生活质量对比研究。结果治疗组客观有效率(CR+PR)为61.7%,优于对照组25.7%,差异有显著性(P<0.05)。治疗组在恶心呕吐、骨髓抑制、食欲改善情况,体重增加,Karnofsky评分提升方面均优于对照组,生活质量明显提高,两组差异有显著性(P<0.05)。结论倍恩联合化疗治疗晚期恶性肿瘤可减轻化疗的毒副反应,改善患者对化疗药物的耐受性,提高其生活质量,增加体重,并有增加疗效的作用。其毒副作用轻,可广泛应用于临床。
Objective To observe the efficacy of Beien in combination with chemotherapy in the treatment of advanced cancer. Methods Sixty-eight tumor patients were randomized into two groups. Tirtyfour cases were treated with Beien in combination with chemotherapy as the trial group, and 34 cases were treated with chemotherapy alone as the control group. Results The remission rate was 61.7% in the trial group, and was better than the control group （25.7% ,P 〈 0.05 ）. The toxicity of both groups was mild. Conclusion Beien could elevate efficacy of chemotherapy in tumor patients. It may relieve the symptoms, improve quality of life, decrease toxic reaction of nausea and vomiting during tumor chemotherapy. Beine may strengthen the efficacy of chemotherapy and relieve the side effects of chemotherapy.
出处
《中国肿瘤临床与康复》
2006年第3期250-252,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
