摘要
目的探讨血清Scc-Ag与子宫颈癌生物学行为及与肿瘤放射治疗疗效的关系。方法应用酶免疫微粒子(MEIA)法检测109例子宫颈鳞癌患者治疗前血清Scc-Ag水平和放射治疗的53例子宫颈鳞癌血清Scc-Ag阳性患者,每周定期检测血清Scc-Ag值观察其下降情况。结果109例治疗前血清Scc-Ag阳性率与临床分期呈正相关,病期越晚Scc-Ag阳性率越高(P<0.005),病理分化与Scc-Ag阳性率无明显的相关性(P>0.05)。53例放疗过程中连续检测Scc-Ag,发现Scc-Ag阴性率随照射剂量的增加、肿瘤负荷的减小而增加。在治疗中或治疗后Scc-Ag持续高水平是较强的危险信号,并提示可能有远处转移或肿瘤未控。结论血清Scc-Ag是子宫颈鳞癌较好的一种肿瘤标记物,定期检测血清Scc-Ag对子宫颈癌的发展状态、淋巴结转移、放射治疗后的疗效以及随访监控具有临床和研究的重要参考意义。
Objective：To investigate the relationship between the per- treatment serum squamous cell carcinoma antigen （Scc -Ag） levels and the radiotherapy treatment response and the biological characteristics in patients with cervical cancer. Methods： The pre -treatment sera from 109 cases with cervical cancer were analyzed for the Scc - Ag levers by MEIA, 53 cases who treated by radiotherapy with high Scc - Ag levers were measurated for Scc - Ag levers every week. Results： Significant correlation was found between the serum of per - treatment serum Scc - Ag levers and clinical stage. The Sec - Ag positive rate increased with elevation of clinical stage（ P 〈 0. 005 ）. No significant correlation was found in tumorous cell pathologic differentiation and Scc - Ag positive rate （ P 〉 0.005 ）. Scc - Ag negative rate increased with increase of exposure dose and decrease of tumor load during radiotherapy treatment. In the course of irradiation or after completion of radiotherapy, a persistently high Scc - Ag level was associated with a high probability of residual growth or the tumor metastasis. Conclusion： Serum Scc - Ag is a good tumor marker of the squamons cell carcinoma of the uterine cervix. Scc - Ag detection regularly is very important for monitoring disease status,lymph node matastasis, curative effect after radiotherapy and follow.
出处
《现代肿瘤医学》
CAS
2006年第7期880-881,共2页
Journal of Modern Oncology
关键词
子宫颈肿瘤
血清鳞状细胞癌抗原
放射治疗
carcinoma of cervix
serum squamous cell carcinoma antigen
radiotherapy treatment
