摘要
目的:探讨TRAb、TGA、TMA在G raves’病131I治疗中的价值,了解131I治疗后早发性甲减产生的机理。方法:对167例G raves’病131I治疗患者进行治疗前及治疗后6个月检测TRAb、TGA、TMA和甲状腺功能,依据治疗后甲状腺功能状况分为甲亢未控制组91例、甲亢控制组48例和早发性甲减组28例,并对这三组治疗前后进行比较。结果:早发性甲减组年龄低于甲亢未控制组(P<0.01)。TRAb治疗前甲亢未控制组高于甲亢控制组和早发性甲减组(P<0.05)。各组治疗前后比较:治疗后甲亢未控制组与甲亢控制组的TRAb均高于治疗前(P<0.05),早发性甲减组的TGA、TMA治疗后高于治疗前(P<0.01)。TGA、TMA治疗后早发性甲减组明显高于甲亢未控制组和甲亢控制组(P<0.01)。结论:①G raves’病患者进行131I治疗时,年龄轻的比年龄大的容易发生早发性甲减;②131I治疗前血清中TRAb水平高的不易治愈,反之,要警惕早发性甲减。③Graves’病患者131I治疗后早发性甲减的发生可能与TGA、TMA阳性率增高有关。
Objective To explore the clinical meanings of changes of serum TRAb, TGA, TMA contents during treatment of Graves＇ disease with ^131Ⅰ, especially in those patients developing early hypothyroidism. Methods Serum levels of TRAb, TGA, TMA, TSH, T3, T4 were measured in 167 patients with Graves＇ disease both before and six months after ^131Ⅰ therapy. Results Six months after ^131Ⅰ treatment, the original 167 patients could be divided into three groups based apon their thyroid ruction statas： Group A, improved but remained hyperthyroid, n = 91, Group B, enthyroid, n = 48, Group C, developing early hypothyroidism, n = 28. Average age in Group C （hypothyroid） was significantly lower than that in Group A （hyperthyroid） （ P 〈 0.05 ）. Before treatment, serum TRAb contents in Group A were significantly higher than those in Group B and Group C （P 〈0.05）. After treatment, TRAb levels in Group A and Group B were significantly higher than those of the respective group before treatment （ P 〈 0.05 ）. The TGA, TMA levels in Group C were significantly higher after treatment than those before treatment （P 〈0. 01 ）. Also after treatment, the TGA, TMA levels in Group C were significantly higher than those in Group A and Group B. Conclusion ①Hypothyroidism developed more frequently after ^131Ⅰ treatment in younger patients. ② Patients with high TRAb levels before ^131Ⅰ therapy were less likely to be rendered enthyroid after a single course of treatment while those with low TRAb levels were easily rendered hypothyroid. ③ Development of hypothyroidism after ^131Ⅰ treatment was closely related to the increase of TGA, TMA levels.
出处
《放射免疫学杂志》
CAS
2006年第3期210-212,共3页
Journal of Radioimmanology
