摘要
目的：探讨恶性肿瘤并上腔静脉阻塞综合征的最佳治疗方式。方法：对102例恶性肿瘤合并上腔静脉阻塞综合征（SVCS）进行回顾性分析，将102例患者分为两组。57例接受化疗（包括40例肺癌、4例恶性胸腺和13例非霍奇金淋巴瘤）．45例患者接受放疗（包括32例肺癌、4例恶性胸腺瘤和9例非霍奇金淋巴瘤）。小细胞肺癌的化疗采用EP方案．非小细胞肺癌采用NP方案，非霍奇金淋巴瘤采用CHOP方案，恶性胸腺瘤采用PAC／EP方案；放疗采用大剂量冲击照射，3～4d后改用常规剂量。结果：放疗组总缓解率（93．4％）高于化疗组（78．9％）（P〈0．05）。治疗第3天，放疗组的缓解率高于化疗组，第21天化疗组和放疗组缓解率相差不大。放疗组非小细胞肺癌缓解率为90．0％，小细胞肺癌为95．5％，恶性胸腺瘤为100％，非霍奇金淋巴瘤为88．9％；化疗组非小细胞肺癌缓解率为60％，小细胞肺癌缓鹪率为92．0％，恶性胸腺瘤为50．0％，非霍奇金淋巴瘤为84．6％。结论：放疗组获得缓解的时间短于化疗组，而对于小细胞肺癌和非霍奇金淋巴瘤，化疗组与放疗组疗效差异无统计学意义。
Objective： To explore the better treatment method for malignant tumor complicated with superior vena cava syndrome （SVCS）. Methods.The treatment methods of 102 patients were retrospectively analyzed by dividing them into two groups ： 57 cases,including 40 lung cancer and 4 malignant thymomas and 13 non-Hodgkin＇s lymphomas （NHL）,were given chemotherapy, 45 patients of them, including 32 lung cancer and 4 malignant thymomas and 9 non-Hodgkin＇s lymphomas（NHL）,were given radiotherapy, the patients of small cell lung cancer were treated with EP regimens, the cases of non-small cell lung cancer were treated with NP regimens, the non-Hodgkin＇s lymphomas （NHL） patients were treated with CHOP regimens, and the malignant thymomas patients were treated with PAC/EP regimens. The methods of radiotherapy included high-dose radiation for 3-4 day then followed by normal-dose radiation. Results： The complete relief rate in radiotherapy was 93. 3%, significantly higher than that of the chemotherapy （78.9%） （P 〈0.05）. The relief rate in the third day of the group with radiotherapy was significantly higher than that of the group with chemotherapy. But the relief rate in 21th day of both groups shows no apparent difference. The objective relief rates were 90.0% in non-small cell lung cancer,95.5% in small cell lung cancer , 100 % in malignant thymomas, 88.9 % in N HL by the radiotherapy. The objective relief rates were 60.0% in non-small cell lung cancer,92.0% in small cell lung cancer ,50.0% in malignant thymomas, 84.6 % in NHL by the chemotherapy. Conclusion： Radiotherapy is significantly more effective than chemotherapy in obtaining relief （P〈0.05）. It is well effective in non-small cell lung cancer and NHL with chemotherapy.
出处
《新疆医科大学学报》
CAS
2006年第6期520-523,共4页
Journal of Xinjiang Medical University
关键词
上腔静脉阻塞综合征
放疗
化疗
superior vena cava syndrome （SVCS）
chemotherapy
radiotherapy
