摘要
目的:探讨5-羟色胺受体3(5-HT3R)在腹泻型肠易激综合征(D-IBS)患者结肠黏膜的改变和临床意义。方法:对18例正常人和28例D-IBS患者行结肠镜检查并分别取升结肠、横结肠、降结肠、乙状结肠黏膜标本2块。应用Westernblotting半定量法检测5-HT3R的表达。结果:D-IBS组4部位5-HT3R的表达皆较正常组增多,差异有显著性(P<0.05)。但在4个部位之间比较5-HT3R的表达无显著性差异。结论:D-IBS患者的结肠5-HT3R表达上调,提示5-HT3R可能为D-IBS分子生物学基础之一,为D-IBS的治疗提供了分子靶点。
Objective: To investigate the changes and the clinical significance of 5-HT3 receptors in colon mucosa in diarrhea prominent irritable bowel syndrome(D-IBS). Methods: The expression of 5-HT3 receptors as measured by western blotting in four biopsies sections from the ascending, transverse, descending, and sigmoid colon of 28 D-IBS patients and 18 healthy controls. Results: Significantly increased expression of 5-HT3 receptors was found in all sections of colon in D-IBS patients compared to controls (P 〈 0.05). Among the four colon sections no significant differences in expression of 5-HT3 receptor were found. Conclusion: The expression of 5-HT3 receptors is significantly increased in D-IBS patients, suggesting that 5-HT3 receptors are involved in the pathogenesis of D-IBS, which may offer a molecular target for treatment.
出处
《南京医科大学学报(自然科学版)》
CAS
CSCD
北大核心
2006年第7期563-566,F0004,共5页
Journal of Nanjing Medical University(Natural Sciences)
基金
苏威全国肠易激综合征研究基金