摘要
本文研究菌草灵芝孢子粉对小鼠化学性肝损伤有辅助保护作用。用50只SPF级昆明种雌性小鼠平均分成3组，其中菌草灵芝孢子粉分0．075g／kg·bw、0．150g／kg·bw、0．450g／kg·bw三个剂量组给小鼠灌胃，对照组给等体积的蒸馏水，共30d。然后分别以50％乙醇（12mL／kg·bw），造成急性肝损伤，观察小鼠的体重、血清肝组织中还原型谷胱甘肽（GSH）的活性及丙二醛（MDA）、甘油三酯（TG）的含量。结果表明在50％乙醇肝损伤模型中，菌草灵芝孢子粉可以非常显著地抑制肝损伤小鼠的血清MDA值的升高，并能提高其血清GSH的活性。在50％乙醇肝损伤模型中，分别以中浓度和高浓度的菌草灵芝孢子粉肝脏保护作用最好。说明菌草灵芝孢子粉可以抑制乙醇产生的自由基造成的脂质过氧化，抑制过多的自由基和脂质过氧化物对肝细胞的破坏作用，从而达到保护肝脏的作用。
To study the hepatoprotecfive active of grass-cultivated Ganoderma lucidum spores powder in mice with liver injure. 50 mice were randomized into 3 groups：three groups of grass-cultivated Ganoderma lucidum spores powder at doses of 0.075 g/kg·bw,0.150 g/kg·bw,0.450 g/kg·bw through gastric tube for 30 days, and then 50% enthanol to induce liver injury model,suggesting that grass-cultivated Ganoderma lucidum spores powder had good protective effect on the hepatocytes in mice with liver injury induced by 50% enthanol as indicated by decreased MDA and TG content and increased activities of plasma GSH. The results showed grass-cultivated Ganoderma lucidum spores powder was protective against 50% enthanol induced liver injury in mice and its effect may be due to its anfioxidative activities in vivo.
出处
《天然产物研究与开发》
CAS
CSCD
2006年第B06期39-41,共3页
Natural Product Research and Development
关键词
菌草灵芝
孢子粉
肝损伤
护肝作用
grass-cultivated Ganoderma lucidum
spores
liver damage
