摘要
目的评价依那普利与氢氯噻嗪(复方依那普利)降压疗效和安全性。方法采用随机、双盲、对照试验,选择轻、中度高血压患者55例,随机入依那普利10mgqd、依那普利10mg与氢氯噻嗪6.25mgqd或依那普利10mg与氢氯噻嗪12.5mgqd试验组,共8周。每2周随访1次,并于治疗后4周和8周进行实验室检查和安全分析。结果降压疗效:治疗2周末依那普利10mgqd组、依那普利10mg与氢氯噻嗪6.25mgqd组及依那普利10mg与氢氯噻嗪12.5mgqd组坐位舒张压(SeDBP)和坐位收缩压(SeSBP)均明显下降(P<0.01),治疗4周末和治疗6周末各治疗组的SeDBP、SeSBP仍继续下降。治疗8周末,两复方依那普利组较依那普利组降压幅度明显(P<0.05),但两复方依那普利组间无差别。结论复方依那普利(依那普利10mg/氢氯噻嗪6.25mg与依那普利10mg/氢氯噻嗪12.5mg)可安全有效降压,作用强于单用依那普利。
Objective To assess the efficacy and safety of enalapril/hydrochlorothiazide combination in patients with mild-tomoderate hypertension. Methods A randomized, double-blind, controlled clinical trial was conducted. All 55patients were randomized to enalapril 10 mg Qd, enalapril 10 mg/hydrochlorothiazide 6.25 mg Qd or enalapril 10 mg/hydrochlorothiazide 12.5 mg Qd group. After 4 weeks, if DBP：〉90 mrnHg, we titrated dosage of enalapril. Results After 8 weeks of treatment, the sitting blood pressure （ BP） was significantly reduced in all groups（ P 〈 0.01）. Diastolic blood pressure （ DBP） were more decreased in the combination group than in the enalapril group, 15.31 mmHg vs 15.46 mmHg vs 10.13 mmHg. The response rate in the combination grouop was higher than in the enalapril group（ P〈 0.05）. Adverse events among groups were comparable. Conclusions enalapril/hydrochlorothiazide combination is effective and safe for patients with mild to moderate hypertension. The BP reduction in enalapril/hydrochlorothiazide combination group is more significant than that induced by enalapril.
出处
《实用全科医学》
2006年第4期481-482,共2页
Applied Journal Of General Practice
关键词
依那普利/氢氯噻嗪
高血压
对照试验
Enalapril/Hydrochlorothiazide combination
Hypertension
Randomized controlled trial
