摘要
目的评价后程加速超分割放射治疗食管癌的疗效及导致治疗失败的因素。方法将本科诊治的89例食管癌患者随机分为2组:常规分割放射组43例,每天2Gy,每周5次,总剂量60Gy,总疗程6周;后程加速超分割放射组46例,前2/3病程放射方法同常规组,4周内照射40Gy,然后缩野进行加速分割照射,每日2次,每次1.5Gy,间隔6h,照射24Gy,总剂量64Gy,疗程6周。所有病例均采用60Co远距离外照射。结果后程加速超分割放射组1、3、5年生存率分别为73.9%、43.4%、32.6%,明显高于常规组的46.5%、20.9%、13.9%(P<0.05)。后程加速超分割放射组患者中随访期死亡17例。结论食管癌患者后程加速超分割放射治疗可以提高局控率,延长患者生存期。
Objective To evaluate the effect of late course accelerated hyperfractionation radiotherapy for esophageal carcinoma and the influential factors. Methods Eight nine cases with esophageal carcinoma were randomly divided into 2 groups. The conventional fractionation group （ n - 43） received routine radiotherapy （2Gy per day, 5 times a week to a total dose of 60Gy in six weeks）, and the late course accelerated hyperfractionation radiotherapy group received the same schedule as conventional group during the first 2/3 of the course of radiotherapy, then followed by accelerated {ractionation using reduced fields chained into 1.5 Gy a day, with an interval of 6 hours between fractions to total dose of 64 Gy. The same 60^Co radiotherapy was used in the both groups. Results The survival rate of 1, 3 and 5 years were 73.9%, 43.4% and 32.6% in the late course hyperfractionation group, whereas 46.5%, 20.9% and 13.9% in the conventional group. There was significant difference between the two groups （ P〈 0.05）. There were 17 cases died in the late course hyperfractionation group in the follow up stage. Conclusions The accelerated hyperfractionation radiotherapy can increase the local control rate and elongate the survival time of patients with esophageal carcinoma.
出处
《实用全科医学》
2006年第4期398-399,共2页
Applied Journal Of General Practice
关键词
食管肿瘤
放射疗法
超分割
预后
Esophageal carcinoma
Radiotherapy
Accelerated hyperfractionation
Prognosis
