摘要
目的初步评价新型钛基材料的血液相容性。方法采用新西兰大白兔新鲜全血,抗凝后分别与实验组和阳性对照、阴性对照组接触,用紫外-可见光分光光度计比色,评价各组的溶血率。实验符合国际化标准组织规定要求。结果新型微弧氧化钛基材料直接接触溶血率为0.79％,符合医用材料的溶血率不大于5％的要求。结论新型钛基材料具有良好的血液相容性。
Objective To assess the blood compatibility of a new type of titanium substrate biomaterial. The aim of this investigation was to determine the influence of surface treatments of commercially pure titanium sampies on in vitro bioactivity. Methods In this study, a new type of titanium substrate biomaterial were contacted with blood. Compared with negative control group （Sodium Chloride） and positive control group （deionized water）, effects of resolution blood of this new material were evaluated. The experiment conformed to standards rules made by ISO. Made the dilution rabbit blood 18ml by mixing anticoagulative dilute cony blood （8ml） and mixing the Sodium Chloride （10ml）. Each test tube was added 0.2ml dilution cony blood and put into 37℃ constant temperature water to keep warm for one hour. Then set test tubes in 37℃ at the UV-Visible Spectrophotometer 545nm wave length place. Results The haemolytic rate of the test group was lower than 5% which was ruled by ISO. The result indicates that this new material has no haematolysis effect. Conclusion The material did not resolve red blood ceils and had good blood compatibility.
出处
《生物骨科材料与临床研究》
CAS
2006年第3期9-10,13,共3页
Orthopaedic Biomechanics Materials and Clinical Study
关键词
微弧氧化
血液相容性
溶血率
Micro-arc Oxidation
blood compatibility. Hemolysis ratio
