摘要
以萘并吡喃酮为原料，通过３种方法合成了标题化合物，其结构经１￣ＨＮＭＲ，ＩＲ，ＭＳ及元素分析确证，并考察对小牛胸腺ＤＮＡ的嵌入活性。
The title compound was synthesized by three methods from naphthopyrone. The structures of this compound and its precursors were fully characterized by 1H NMR, MS, IR and elemental analysis.Its DNA-intercalative activity was investigated in DMSO-Tris HCl system by fluorescence quenching technique and the apparent Scatchard binding constant was estimated. Results showed that it efficiently intercalated into DNA.The spectral properties and DNA-intercalative activity have been compared with those of its analogues.
出处
《应用化学》
CSCD
北大核心
1996年第4期34-37,共4页
Chinese Journal of Applied Chemistry
基金
国家自然科学基金
国家教委重点博士点基金
优秀年轻教师基金
关键词
萘并吡喃酮
DNA
嵌入
光谱
荧光淬灭
naphthopyrones
DNA intercalation activity
synthesis
spectrum
