摘要
目的 探讨固骼生（NovaBone）早期植入治疗高能量胫骨骨折的疗效。方法98例采用切开复位交锁髓内钉内固定的高能量胫骨骨折患者随机被分为实验组50例和对照组48例。前者行早期预防性骨折断端固骼生植入，后者不植入固骼生。结果随访平均8个月。骨折平均愈合时间实验组为8～16周（平均12周），无延迟愈合和骨不连；对照组为12～36周（平均19周），5例延迟愈合（愈合时间7～8个月）。按照Johner和wruh标准评定。术后12周和26周时，实验组优趋率分别为86％和100％，对照组为50%和89％，两组有非常显著性差异（P〈0．01）。结论固骼生早期预防性植入配合交锁髓内钉内固定治疗高能量胫腓骨骨折，能加速骨折愈合，降低延迟愈合或骨不连发生率。
Objective To summarize the effect of early prophylactic NovaBone grafting of highenergy tibial shaft fractures. Methods From May, 2002 to February, 2005, 98 cases of high-energy tibial shaft fractures were treated with reamed interlocking nail. Patients were randomized into the experimental group of 50 cases （the fractured site were received early prophylactic NovaBone graft） , and the control group of 48 cases （did not receive NovaBone）. Results The averaging 8 months follow-up evaluation was made to all patients. The mean time to fracture healing was 12 weeks（range, 8- 16 weeks） in the experimental group, was 19 weeks （range, 12-36weeks） in the control group （P 〈 0, 01）. In the experimental group, no delayed union or nonunion, but in the control group, there were 5 fractures （10,4 % ） healed spontaneously in a period from 7 and 8 months, When the data were analyzed according to the criteria of Johner and Wruh, by week 12 and 26, there were excellent rate 86 % and 100 % in the experimental group, 50 % and 89 % in the control group respectively, significant difference was found between the two groups（P 〈 0. 01 ）. Conclusion We found early prophylactic NovaBone grafting is safe and well tolerated, and it reduces the necessity of secondary interventions to promote fracture-healing of high-energy tibial fractures.
出处
《苏州大学学报（医学版）》
CAS
北大核心
2006年第3期467-469,共3页
Suzhou University Journal of Medical Science
关键词
固骼生
胫骨骨折
治疗
骨折愈合
NovaBone
tibial fractures
treatment
fracture-healing
