摘要
目的观察短期甘精胰岛素用于初次诊断的2型糖尿病(T2DM)患者的降糖效果及胰岛B细胞功能和胰岛素敏感性的改变。方法28例初次诊断的T2DM并高血糖(空腹血糖≥11mmol/L)患者,给予2周甘精胰岛素强化治疗(三餐配合使用速效胰岛素);停药随诊观察。结果2周甘精胰岛素强化治疗显示稳定、快速降糖效果,治疗后口服糖耐量试验出现明显增加的C肽曲线下面积;胰岛素分泌指数明显增加;胰岛素抵抗指数显著改善。复诊患者中最长的已经半年不用药物,仅靠控制饮食和运动就能很好地控制血糖。结论对伴明显高血糖的初次诊断的T2DM,短期甘精胰岛素强化治疗可以快速、稳定控制血糖,显著改善胰岛B细胞功能和胰岛素敏感性。
Objective To investigate the effect of short-term insulin glargine on plasma glucose, beta-cell function and insulin resistance in newly diagnosed type 2 diabetes mellitus （ T2DM ） patients. Methods 28 newly diagnosed T2DM cases complicated with hyperglycemia（fasting plasma glucose 〉 11mmol/L） were treated with glargine insulin aspart for two weeks （ at meal time ）. The patients were followed up after the withdrawal of medicine. Results The excellent control of plasma glucose was achieved after 2 weeks treatment with glargine insulin. Betecell function was dramatically improved. The secretion index of insulin and C-peptide curve area as well as Homa-β were significantly increased during OGTT. Re-examined patients stopped use of medicine for at most half years ,whose plasma glucose could be controlled only by the controlling of diet and excises. Conclusion The excellent glucose control, improvement of beta-cell function, and amelioration of insulin resistance can be induced by short-term glargine treatment in newly diagnosed type 2 diabetic patients.
出处
《中国医药》
2006年第3期161-162,共2页
China Medicine
关键词
2型糖尿病
甘精胰岛素
胰岛B细胞功能
Type 2 diabetes mellitus
Insulin glargine
Beta-cell function of insulin
