摘要
目的:观察枳实消痞汤颗粒对小鼠的急性毒性和对大鼠的长期毒性。方法:急性毒性实验:用枳实消痞汤颗粒(104g/kg)给小鼠灌胃,观察动物的一般活动情况及死亡数;长期毒性实验:用枳实消痞汤颗粒(25、12.5、6.25g/kg)给大鼠连续灌服32天,停药14天,观察大鼠的生长发育、血液学和血液生化学指标、脏器系数并作组织病理学检查。结果:急性毒性实验显示小鼠无一死亡;长期毒性实验显示大鼠的进食量、行为、体重、脏器系数和血清生化指标与空白对照组比较,均无明显差异。结论:枳实消痞汤颗粒的临床拟用量是安全的。
Objective ： To observe acute toxicity in mice and chronic toxicity in rat of Zhishixiaopitang Granule. Methods： Zhishixiaopitang Granale （104g/kg） was gived to mice by garage, then to observe the general condition and mortality of mice in acute toxicity. In chronic toxicity , Zhishixiaopitang Granule（25,12.5.6.25g/kg） was gived to rats by gavage for 32 days ,the toxic affection during treatment and the recovery addition within 14 days of stopping treatment were observed. Results ： There is no death for mice of acute toxicity test. There is no significant difference in food, behavior ,weight, blood index and blood biological indexes, organ coefficient and organ pathology between the experimental and the control group. Conclusion： It is safe at clinical dosage of Zhishixiaopitang Granule
出处
《中药药理与临床》
CAS
CSCD
北大核心
2006年第1期15-18,共4页
Pharmacology and Clinics of Chinese Materia Medica
关键词
枳实消痞汤
急性毒性
长期毒性
Zhishixiaopitang granule （枳实消痞颗粒）
acute toxicity
chronic toxicity
