摘要
目的探讨C反应蛋白质(CRP)评估克罗恩病(CD)活动性的作用。方法Logistic回归分析81例CD患者血清CRP与血沉(ESR)、临床活动指数(CDAI)、内镜活动性、组织学活动性、低白蛋白血症、贫血;比较临床严重程度和病变部位及药物治疗对CRP的影响。结肠镜活检组织核因子κBp65(NFκBp65)免疫组织化学染色。结果CRP与ESR相关;与CDAI、内镜活动性、组织学活动性、低白蛋白血症、贫血无相关性;CRP在活动性CD中显著升高(P<0.01),在重度和结肠CD升高较明显(P<0.05)。药物有效控制病情时CRP显著下降(P<0.01),复发时重新升高(P>0.05);NF-κBp65在CD中表达增强(P<0.01),与血清CRP升高有一致性(P=1.0)。结论CRP升高更适于反映中、重度结肠CD的活动性;快速反映药物治疗的有效性;血清CRP升高与NF-κB p65的表达增强有一致性,值得进一步研究。
Objective To investigate the role of C-reactive protein （CRP） in evaluating activity of Crohn＇s disease （CD）. Methods 85 patients with Crohn＇s disease, 59 males and 26 females, aged 15 - 69, underwent laboratory examination of CRP, erythrocyte sedimentation rate （ESR）, albumin, and hemoglobin. Crohn＇s disease activity index （CDAI） was calculated. Endoscopy was conducted to collect samples of colon mucosa to undergo HE staining for pathological examination and immunohistochemical staining for the expression of nuclear factor-κB p65 （ NF-κB p65）. Logistic regression analysis was used to estimate the correlation of CRP with ESR, CDAI, endoscopic activity, pathologic activity, hypoalbuminemia, and anemia. The effects of lesion location, clinical severity, and drug were considered. Results CRP elevation was correlated with ESR, but not correlated with CDAI, endoscopic activity, pathologic activity, hypoalbuminemia, and anemia. CRP was significantly elevated in active C D （P 〈 0.01 ）, especially in severe or colonic CD（ P 〈 0.05）. CRP rapidly decreased when the CD activity was effectively controlled by drugs （ P 〈 0. 01 ）, and was reelevated when disease recurred （ P 〉 0.05 ）. Serum CRP elevation was paralleled with the NF-κB p65 level（ P = 1.0）. Conclusion More suitable for refection of the activity of moderate or severe colonic CD, CRP can reflect the effects of drugs in the early stage of CD. The serum CRP elevation is consistent with the NF-κB p65 expression in colon tissues.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2006年第18期1253-1255,共3页
National Medical Journal of China
基金
上海市重点学科建设项目基金资助(Y0205)
关键词
C反应蛋白质
血沉
CROHN病
C-reactive protein
Blood sendimentation
Crohn disease
