摘要
目的通过对国内有关继发性肺结核与PPD皮试联系的病例对照研究结果进行荟萃分析（meta analysis），获得综合的结论，以期对PPD皮试作为诊断实验在诊断继发性肺结核中的意义作出评价。方法以“PPD”为关键词，选用中国学术期刊全文数据库（cHKD），检索1994—2006年国内已发表的相关文献，选择符合标准的文献进行荟萃分析。对所有研究予以加权定量合并，计算灵敏度和特异度及其95％可信区间。绘制汇总受试者工作特征曲线（SROC），并计算曲线下面积。结果共纳入8篇中文文献，研究对象共计1479人，按照随机效应模型计算汇总数据，得优势比为exp（A）=e）cp（2．2998）=9．9726，可以认为异常组阳性优势明显高于正常组。诊断试验的准确度指标TPR＊=0．7595，其标准误亚（TPR＊）=0．04915。结论汇总目前关于PPD皮试诊断继发性肺结核的研究显示，PPD皮试是一种准确度较高的检查方法，但还需要高质量的前瞻性研究以更准确地评价其临床价值。
Objective To conduct a meta- analysis of RCT studies of the associaton between PPD skin test and pumonary tubereulosis. To assess the diagnostic value of PPD skin test in patients with the pulmonary tuberculosis. Methods A search in CHDK database was performed to identify relevant articles from 1994 to 2006. Include the studies that obey the criteria for inclusion. Subsequendy,the characteristies of the included articles were appraised and extracted. Then to calculate pooled weighted sensitivity and specificity.Sunmary Receivex Operating Characteristic （SROC） curve was performed and the area under the curve（AUC）was calculated.Results 8 studies were included, involed a total of 1479 persons. The datum were pooled by using radom-effects models.The calculated OR = exp（A） = exp（2.2998） = 9.9726. That is to say, the positve rate of patients is far beyond one of the normal person. Condusion PPDskin test has a highly accurate sensitivity and specificity making it an alternative non-invasive method in the diagnosis of pumonary tuberculosis.
出处
《中国实验诊断学》
2006年第6期616-618,共3页
Chinese Journal of Laboratory Diagnosis
关键词
PPD
继发性肺结核
诊断
荟萃分析
PPD skin test
pumonary tuberculosis
dignosis
meta-analysis
