摘要
用扫描隧道显微镜观察了兔Ｓ抗原及其与鼠抗兔Ｓ抗原抗体相互作用所形成的复合物，结果表明，Ｓ抗原单体呈椭球状。其二维尺寸为７．５ｎｍ×５．３ｎｍ，且常以二聚体形式存在。抗原分别结合于抗体的二个Ｆａｂ段，既可以单体结合，也可以二聚体形式结合。
Rabbit S antigen and its complex with antibody have been observed by scanning tunneling microscope(STM). The results showed that S antigen monomer appeared as ellipsoids, its two dimensional sizes are 7. 5 ×5. 3 nm,usually they existed as dimers or even polymers. Antigens combine with the two ends of Fab in the IgG molecule separately. They may be in the form of either monomers or dimers. This work illustrated the applicability of STM in the investigation of the interaction between antigen and antibody at the molecular level.
基金
国家教委博士点基金
国家自然科学基金
关键词
S抗原
抗原抗体复合物
扫描隧道显微镜
Scanning tunneling microscope, S antigen, Antigen/antibody complex
