摘要
目的探讨急性口服甲醇中毒血甲醇浓度与代谢性酸中毒的关系及其对血液透析(HD)适应症的影响。方法观察53例急性口服甲醇中毒患者血液甲醇浓度(M)、血二氧化碳结合力(CO2CP)和阴离子间隙(AG),按是否行HD治疗分为HD治疗组(GHD)、非HD治疗组(GNHD);用气相色谱顶空进样法(GC)测定M;并按不同M水平进行分析。结果①两组间logM、CO2CP和AG均有显著差异;②M在0.5～7.8mmol/L时,两组间出现例数无显著性差异;③CO2CP<15mmol/L的HD患者中,大部分(22例,85%)M<15.6mmol/L,其中有18例(69%)M<7.8mmol/L。结论在应用M>15.6mmol/L作为HD适应征时,应充分考虑其与代谢性酸中毒的关系。
Objective To investigate the relationship between blood methanol and metabolic acidosis and the influence to the indication of hemodialysis in oral methanol poisoning.Methods 53 oral methanol poisoning were divided to GHD and NGHD according to whether treated by hemodialysis（HD）,blood methanol concentration（M）was measureed by gas chromatography（GC）;M, Carbon dioxide combination power（CO2CP） and Anion gap（AG） were observed. Analysis was made according to different M. Results ①The logM, CO2CP, AG in GHD patients were significant higher than those in NGHD respectively（P = 0.0001 P= 0.0001 P=0.0009 respectively）;②The cases of M lies in 0.5 -7. 8mmo]/L were no obvious difference between the two groups before hemodialysis（p =0. 1444）;③In GHD, with CO2CP （15mmol/L, M〈15.6mmol/L was found in 22 cases（85%）, and M〈7.8mmo]/L was found in 18 cases（69%）. Conclussion It is important to consider the relationship between M and metabolic acidosis in oral methanol poisoning when M〉 15,6mmol/L be used in hemodialysis indication.
出处
《国际医药卫生导报》
2006年第9期10-11,共2页
International Medicine and Health Guidance News
关键词
甲醇
中毒
代谢性酸中毒
血液透析
methanol poisoning metabolic acidosis hemodialysis
